Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Cash flows from operating activities:
Net income (loss)	$ (51,668)	$ (222,290)
Adjustments to reconcile net income (loss) to net cash used in operating activities:
Depreciation and amortization	2,052	2,358
Stock-based compensation expense	11,145	21,298
Gain from sale of priority review voucher	(92,930)	0
Loss (gain) on equity securities	0	3,135
Excess inventory reserve	3,939	7,519
Other non-cash items	343	661
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(9,082)	(9,629)
Inventory	(16,496)	0
Operating lease right-of-use assets	24,102	17,636
Accounts payable	(14,767)	(1,175)
Accrued expenses and other liabilities	3,625	(28,565)
Operating lease liabilities	(19,488)	(10,602)
Deferred revenue	(138)	0
Net cash used in operating activities	(159,363)	(219,654)
Cash flows from investing activities:
Purchase of property, plant and equipment	(937)	(6,836)
Purchases of marketable securities	(34,418)	0
Proceeds from maturities of marketable securities	26,521	108,225
Proceeds from sales of marketable securities	5,853	30,213
Purchase of intangible assets	(868)	0
Proceeds from sale of priority review voucher	92,930	0
Net cash provided by investing activities	89,081	131,602
Cash flows from financing activities:
Proceeds from exercise of stock options and ESPP contributions	85	0
Net cash provided by financing activities	130,011	8,043
(Decrease) increase in cash, cash equivalents and restricted cash	59,729	(80,009)
Cash, cash equivalents and restricted cash at beginning of period	158,445	206,693
Cash, cash equivalents and restricted cash at end of period	218,174	126,684
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	172,872	81,499
Restricted cash included in receivables and other current assets	1,364	1,635
Restricted cash included in restricted cash and other non-current assets	43,938	43,550
Total cash, cash equivalents and restricted cash	218,174	126,684
Supplemental cash flow disclosures from investing and financing activities:
Purchases of property, plant and equipment included in accounts payable and accrued expenses	2,290	842
Right-of-use assets obtained in exchange for operating lease liabilities	44,968	218,836
Reduction of right of use asset and associated lease liability due to lease reassessment	(14)	0
Cash paid during the period for income taxes	7	0
Private Placement
Cash flows from financing activities:
Proceeds from issuance of common stock	(196)	0
Public Offering
Cash flows from financing activities:
Proceeds from issuance of common stock	$ 130,122	$ 8,043