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Stock-based compensation (Tables)
 6 Months Ended
Jun. 30, 2023
Share-Based Payment Arrangement [Abstract]  
Summary of Stock-Based Compensation Expense by Award Type Stock-based compensation expense recognized by award type is included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands):
For the three months ended June 30,For the six months ended June 30,

2023202220232022
Stock options
$1,710 $3,685 $3,433 $8,945 
Restricted stock units
3,969 4,850 7,637 11,884 
Employee stock purchase plan and other75 372 75 469 
$5,754 $8,907 $11,145 $21,298 
Schedule of Stock-Based Compensation Expense by Classification
Stock-based compensation expense by classification included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands): 
For the three months ended June 30,For the six months ended June 30,
2023202220232022
Cost of product revenue(10)— 93 — 
Selling, general and administrative2,681 3,652 5,042 9,488 
Research and development3,083 5,255 6,010 11,810 
$5,754 $8,907 $11,145 $21,298 
Summary of Stock Option Activity Under Plan The following table summarizes the stock option activity under the Company’s equity award plans and have been adjusted to reflect the effects of the November 2021 separation of our severe genetic disease and oncology programs into two separate, publicly traded companies:
Shares
(in thousands)
Weighted-
average
exercise price
per share
Outstanding at December 31, 20222,668 $24.38 
Granted
1,974 $5.04 
Exercised
(3)$2.74 
Canceled or forfeited(210)$22.51 
Outstanding at June 30, 20234,429 $15.91 
Exercisable at June 30, 20231,425 $34.27 
Vested and expected to vest at June 30, 20234,429 $15.91 
Summary of Restricted Common Stock Awards The following table summarizes the restricted stock unit activity under the Company’s equity award plans:
Shares
(in thousands)		Weighted-
average
grant date
fair value
Unvested at December 31, 20222,415 $11.44 
Granted
2,943 $4.97 
Vested
(420)$17.11 
Forfeited
(301)$9.10 
Unvested at June 30, 20234,637 $7.25