Accrued expenses and other current liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
Accrued manufacturing costs	$ 17,226	$ 15,722
Accrued goods and services	9,692	24,273
Accrued clinical and contract research organization costs	13,609	17,769
Accrued employee compensation	19,163	41,095
Accrued professional fees	1,523	1,665
Deferred revenue, current portion	1,565	2,282
Other	1,536	1,152
Total accrued expenses and other current liabilities	$ 64,314	$ 103,958