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Stock-based compensation (Tables)
 9 Months Ended
Sep. 30, 2022
Share-Based Payment Arrangement [Abstract]  
Summary of Stock-Based Compensation Expense by Award Type Stock-based compensation expense recognized by award type is included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands):
For the three months ended September 30,For the nine months ended
September 30,

2022
2021(1)
2022
2021(1)
Stock options
$2,886 $10,759 $11,829 $41,048 
Restricted stock units
6,142 7,276 18,027 23,449 
Employee stock purchase plan and other184 3,219 653 11,177 
$9,212 $21,254 $30,509 $75,674 
(1) Prior period amounts have been retrospectively adjusted to reflect the effects of the Separation.
Schedule of Stock-Based Compensation Expense by Classification Stock-based compensation expense by classification included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands): 
For the three months ended September 30,For the nine months ended
September 30,
2022
2021(1)
2022
2021(1)
Research and development$5,237 $9,016 $17,047 $31,742 
Selling, general and administrative3,975 12,238 13,462 43,932 
$9,212 $21,254 $30,509 $75,674 
(1) Prior period amounts have been retrospectively adjusted to reflect the effects of the Separation.
Summary of Stock Option Activity Under Plan The following table summarizes the stock option activity under the Company’s equity award plans and have been adjusted to reflect the effects of the Separation:
Shares
(in thousands)
Weighted-
average
exercise price
per share
Outstanding at December 31, 20213,586 $39.23 
Granted
1,034 $7.37 
Exercised
(2)$1.04 
Canceled or forfeited(1,893)$40.74 
Outstanding at September 30, 20222,725 $27.78 
Exercisable at September 30, 20221,231 $45.69 
Vested and expected to vest at September 30, 20222,725 $27.78 
Summary of Restricted Common Stock Awards The following table summarizes the restricted stock unit activity under the Company’s equity award plans and have been adjusted to reflect the effects of the Separation:
Shares
(in thousands)		Weighted-
average
grant date
fair value
Unvested at December 31, 20213,193 $16.21 
Granted
1,504 $7.40 
Vested
(860)$17.53 
Forfeited
(1,485)$12.57 
Unvested at September 30, 20222,352 $12.44