Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities:
Net loss	$ (222,290)	$ (447,510)
Adjustments to reconcile net loss to net cash used in operating activities:
Change in fair value of contingent consideration	0	416
Depreciation and amortization	2,358	11,353
Stock-based compensation expense	21,298	73,687
Loss (gain) on equity securities	3,135	(28,286)
Excess inventory reserve	7,519	15,084
Other non-cash items	661	6,228
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(9,629)	(3,481)
Operating lease right-of-use assets	17,636	15,074
Accounts payable	(1,175)	7,475
Accrued expenses and other liabilities	(28,565)	17,453
Operating lease liabilities	(10,602)	(16,468)
Net cash used in operating activities	(219,654)	(348,975)
Cash flows from investing activities:
Purchase of property, plant and equipment	(6,836)	(9,204)
Purchases of marketable securities	0	(196,145)
Proceeds from maturities of marketable securities	108,225	557,751
Proceeds from sales of marketable securities	30,213	31,318
Purchase of intangible assets	0	(2,000)
Net cash provided by investing activities	131,602	381,720
Cash flows from financing activities:
Proceeds from exercise of stock options and ESPP contributions	0	4,192
Proceeds from the secondary public offering, net of issuance costs	8,043	0
Net cash provided by financing activities	8,043	4,192
(Decrease) increase in cash, cash equivalents and restricted cash	(80,009)	36,937
Cash, cash equivalents and restricted cash at beginning of period	206,693	373,728
Cash, cash equivalents and restricted cash at end of period	126,684	410,665
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	81,499	353,468
Restricted cash included in receivables and other current assets	1,635	2,687
Restricted cash included in restricted cash and other non-current assets	43,550	54,510
Total cash, cash equivalents and restricted cash	126,684	410,665
Supplemental cash flow disclosures from investing and financing activities:
Purchases of property, plant and equipment included in accounts payable and accrued expenses	842	1,508
Right-of-use assets obtained in exchange for operating lease liabilities	218,836	22,049
Issuance of unrestricted stock awards to settle accrued employee compensation	0	12,013
Purchases of intangible assets included in accounts payable and accrued expenses, net of reimbursement receivable from collaboration partner	$ 0	$ 6,500