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Stock-based compensation (Tables)
6 Months Ended
Jun. 30, 2022
Share-Based Payment Arrangement [Abstract]  
Summary of Stock-Based Compensation Expense by Award Type Stock-based compensation expense recognized by award type is included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands):
For the three months ended June 30,For six months ended June 30,

2022
2021(1)
2022
2021(1)
Stock options
$3,685 $13,863 $8,945 $30,289 
Restricted stock units
4,850 5,956 11,884 16,173 
Employee stock purchase plan and other372 3,307 469 7,958 
$8,907 $23,126 $21,298 $54,420 
(1) Prior period amounts have been retrospectively adjusted to reflect the effects of the Separation.
Schedule of Stock-Based Compensation Expense by Classification Stock-based compensation expense by classification included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands): 
For the three months ended June 30,For six months ended June 30,
2022
2021(1)
2022
2021(1)
Research and development$5,255 $10,336 $11,810 $22,726 
Selling, general and administrative3,652 12,790 9,488 31,694 
$8,907 $23,126 $21,298 $54,420 
(1) Prior period amounts have been retrospectively adjusted to reflect the effects of the Separation.
Summary of Stock Option Activity Under Plan The following table summarizes the stock option activity under the Company’s equity award plans and have been adjusted to reflect the effects of the Separation:
Shares
(in thousands)
Weighted-
average
exercise price
per share
Outstanding at December 31, 20213,586 $39.23 
Granted
967 $7.48 
Exercised
(2)$1.04 
Canceled or forfeited(1,482)$41.11 
Outstanding at June 30, 20223,069 $29.48 
Exercisable at June 30, 20221,296 $51.24 
Vested and expected to vest at June 30, 20223,069 $29.48 
Summary of Restricted Common Stock Awards The following table summarizes the restricted stock unit activity under the Company’s equity award plans and have been adjusted to reflect the effects of the Separation:
Shares
(in thousands)
Weighted-
average
grant date
fair value
Unvested at December 31, 20213,193 $16.21 
Granted
1,451 $7.51 
Vested
(293)$25.65 
Forfeited
(1,076)$12.67 
Unvested at June 30, 20223,275 $12.70