Supplemental cash flow disclosures:
Supplemental Cash Flow Information [Abstract]
Operating lease liability, net of current portion
Operating Lease, Liability, Noncurrent
Measurement Frequency
Measurement Frequency [Domain]
Vested (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period
Leasehold improvements
Leasehold Improvements [Member]
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Domain]
Net loss
Net loss
Net loss
Net Income (Loss) Attributable to Parent
Discontinued Operations and Disposal Groups [Abstract]
Operating lease right-of-use assets
Operating Lease, Right-of-Use Asset
Preferred stock, shares outstanding (in shares)
Preferred Stock, Shares Outstanding
Accrued employee compensation
Employee-related Liabilities, Current
Income Statement Location
Income Statement Location [Axis]
Statistical Measurement
Statistical Measurement [Domain]
Accumulated deficit
Accumulated deficit
Retained Earnings (Accumulated Deficit)
Marketable securities
Marketable Securities Unrealized Loss
Marketable securities unrealized loss.
Restricted stock units
Restricted Stock Units (RSUs) [Member]
Statement of Stockholders' Equity [Abstract]
Statement of Stockholders' Equity [Abstract]
Purchase of common stock under ESPP (in shares)
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Entity Filer Category
Entity Filer Category
Operating lease right-of-use assets
Lessee, Increase (Decrease) In Operating Lease, Right-of-Use Asset
Lessee, Increase (Decrease) In Operating Lease, Right-of-Use Asset
Security Exchange Name
Security Exchange Name
Equity securities
Investment at fair value
Equity Securities, FV-NI, Current
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Research and development
Disposal Group, Including Discontinued Operation, Research and Development Expense
Disposal Group, Including Discontinued Operation, Research and Development Expense
Forfeited (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Reconciliation of cash, cash equivalents and restricted cash:
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents [Abstract]
Income Statement [Abstract]
Income Statement [Abstract]
Entity Registrant Name
Entity Registrant Name
Vesting of restricted stock units (in shares)
Stock Issued During Period Shares Vesting Of Restricted Stock Units
Stock issued during period shares vesting of restricted stock units.
Restricted cash and other non-current assets
Other Assets, Noncurrent
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]
Computer equipment and software
Computer Equipment And Software [Member]
Computer equipment and software.
Number of shares available for issuance (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant
Anticipated cost savings associated with restructuring, period of recognition
Restructuring And Related Cost, Expected Cost, Period Of Recognition
Restructuring And Related Cost, Expected Cost, Period Of Recognition
(Decrease) increase in cash, cash equivalents and restricted cash
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Interest receivable, write-offs
Interest Receivable, Write-Off
Interest Receivable, Write-Off
Entity File Number
Entity File Number
Income tax (expense) benefit
Income Tax Expense (Benefit)
Stock-based compensation
APIC, Share-based Payment Arrangement, Increase for Cost Recognition
Related party expense
Related Party Transaction, Expenses from Transactions with Related Party
Amendment Flag
Amendment Flag
Equity securities
Equity Securities Unrealized Loss
Equity securities unrealized loss.
Equity Components
Equity Components [Axis]
Selling, general and administrative
Disposal Group, Including Discontinued Operation, General and Administrative Expense
Entity Tax Identification Number
Entity Tax Identification Number
Canceled or forfeited (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period
Fair Value Disclosures [Abstract]
Fair Value Disclosures [Abstract]
Loss on fixed assets disposal
Gain (Loss) on Disposition of Assets
Antidilutive Securities
Antidilutive Securities [Axis]
Investment Type
Investment Type [Axis]
Discontinued operations
Disposal Groups, Including Discontinued Operations, Disclosure [Text Block]
Document Fiscal Period Focus
Document Fiscal Period Focus
Assembly Row Lease
Assembly Row Lease [Member]
Assembly Row Lease
Total current assets
Assets, Current
Initial term of transition services agreement
Transition Services Agreement, Initial Term
Transition Services Agreement, Initial Term
Forfeited (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Marketable securities
Marketable Securities Amortized Cost
Marketable securities amortized cost.
Lessee, Lease, Description [Line Items]
Lessee, Lease, Description [Line Items]
Subsequent Event Type [Domain]
Subsequent Event Type [Domain]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Operating lease liabilities
Increase Decrease In Operating Lease Liabilities
Increase (decrease) in operating lease liabilities.
Statement of Financial Position [Abstract]
Statement of Financial Position [Abstract]
Common stock equivalents excluded from the calculation of diluted net loss per share (in shares)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Cost of royalty and other revenue
Disposal Group, Including Discontinued Operation, Costs of Goods Sold
Research and development
Research and Development Expense [Member]
Product and Service
Product and Service [Axis]
Property, Plant and Equipment, Type
Long-Lived Tangible Asset [Domain]
Subsequent Events [Abstract]
Restructuring Plan [Axis]
Restructuring Plan [Axis]
Preferred stock, par value (in dollars per share)
Preferred Stock, Par or Stated Value Per Share
Change in fair value of contingent consideration
Disposal Group, Including Discontinued Operation, Change in Amount of Contingent Consideration, Liability
Disposal Group, Including Discontinued Operation, Change in Amount of Contingent Consideration, Liability
Granted (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Equity Component
Equity Component [Domain]
Fair value
Debt Securities, Available-for-sale, Fair Value [Abstract]
Debt Securities, Available-for-sale, Fair Value
Proceeds from maturities of marketable securities
Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-sale
Issuance of unrestricted stock awards to settle accrued employee compensation (in shares)
Shares Issued, Shares, Share-based Payment Arrangement, after Forfeiture
Disposal Group Name [Axis]
Disposal Group Name [Axis]
Shares of common stock issued under plan (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period
Award Type
Award Type [Domain]
Disposal Group Name [Domain]
Disposal Group Name [Domain]
Outstanding stock options
Equity Option [Member]
Local Phone Number
Local Phone Number
Assets
Assets [Abstract]
Lease renewal term
Lessor, Operating Lease, Renewal Term
Accrued expenses and other liabilities
Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities
Marketable securities
Marketable Securities, Noncurrent
Exercisable at end of period (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number
Statement [Line Items]
Statement [Line Items]
Vested and expected to vest at end of period (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Restricted cash included in restricted cash and other non-current assets
Restricted Cash, Noncurrent
Granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period
Weighted- average exercise price per share
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]
Debt securities, available-for-sale, noncurrent
Debt Securities, Available-for-sale, Noncurrent
Preferred stock, $0.01 par value, 5,000 shares authorized; 0 shares issued and outstanding at March 31, 2022 and December 31, 2021
Preferred Stock, Value, Issued
Proceeds from exercise of stock options and ESPP contributions
Proceeds, Issuance of Shares, Share-based Payment Arrangement, Including Option Exercised
Issuance of unrestricted stock awards to settle accrued employee compensation
Shares Issued, Value, Share-based Payment Arrangement, after Forfeiture
Outstanding at beginning of period (in shares)
Outstanding at end of period (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number
Summary of Stock-Based Compensation Expense by Award Type
Share-based Payment Arrangement, Cost by Plan [Table Text Block]
Debt securities
Debt Securities, Available-for-sale
Accumulated deficit
Retained Earnings [Member]
Prepaid expenses and other assets
Increase (Decrease) in Prepaid Expense and Other Assets
Amortized cost / Cost
Debt Securities, Available-for-sale [Abstract]
Decrease in purchase commitments
Purchase Obligation, Cumulative Increase (Decrease)
Purchase Obligation, Cumulative Increase (Decrease)
Commitments and contingencies
Commitments and Contingencies Disclosure [Text Block]
Significant other observable inputs (Level 2)
Fair Value, Inputs, Level 2 [Member]
Property, Plant and Equipment, Type
Long-Lived Tangible Asset [Axis]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Number of transition services agreements
Number of Transition Services Agreements
Number of Transition Services Agreements
Total
Debt Securities, Available-for-sale, Unrealized Loss Position
Summary of Available-for-sale Debt Securities in Continuous Unrealized Loss Position
Debt Securities, Available-for-sale, Unrealized Loss Position, Fair Value [Table Text Block]
Debt securities
Debt Securities, Available-for-sale, Amortized Cost
Total revenues
Disposal Group, Including Discontinued Operation, Revenue
Income tax benefit (expense)
Discontinued Operation, Tax Effect of Discontinued Operation
Purchases of property, plant and equipment included in accounts payable and accrued expenses
Capital Expenditures Incurred but Not yet Paid
Right-of-use assets obtained in exchange for operating lease liabilities
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Use of estimates
Use of Estimates, Policy [Policy Text Block]
Granted (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross
April 2022 Reduction
April 2022 Reduction [Member]
April 2022 Reduction
Property, Plant and Equipment [Line Items]
Property, Plant and Equipment [Line Items]
Other comprehensive income (loss)
Other comprehensive income
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Schedule of Stock-Based Compensation Expense by Classification
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Title of 12(b) Security
Title of 12(b) Security
Accounts payable to related party
Due to Related Parties
Other comprehensive income (loss), tax
Other Comprehensive Income (Loss), Tax
Total assets
Assets
Common stock, shares authorized (in shares)
Common Stock, Shares Authorized
Number of operating segments
Number of Operating Segments
Other (Expense) Income, Net
Other Nonoperating Income (Expense) [Member]
Net loss per share - basic (in dollars per share)
Earnings Per Share, Basic
Unrealized losses
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain (Loss), before Tax [Abstract]
Anticipated cost savings associated with restructuring
Restructuring and Related Cost, Expected Cost
U.S. government agency securities and treasuries
US Treasury and Government [Member]
Document Type
Document Type
Summary of Restricted Common Stock Awards
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]
Accrued expenses and other current liabilities
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]
Research and development
Research and Development Expense
Product and Service
Product and Service [Domain]
Unvested balance at beginning of period (in shares)
Unvested balance at end of period (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Depreciation and amortization
Depreciation, Depletion and Amortization, Nonproduction
2seventy bio
2seventy bio [Member]
2seventy bio
Prepaid expenses
Prepaid Expense, Current
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
ESPP shares and other
Employee stock purchase plan and other
Employee Stock Purchase Plan And Other [Member]
Employee stock purchase plan.
Equity securities
Equity Securities, FV-NI, Cost
Accounts receivable due from related party
Due from Related Parties
Shares (in thousands)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Measurement Frequency
Measurement Frequency [Axis]
Net cash used in operating activities
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Fair Value, Recurring and Nonrecurring [Table]
Fair Value, Recurring and Nonrecurring [Table]
Marketable securities
Marketable Securities Unrealized Gains
Marketable securities unrealized gains.
Commercial paper
Commercial Paper [Member]
Common shares reserved for future issuance (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized
Corporate bonds
Corporate Bond Securities [Member]
Other non-cash items
Other Noncash Income (Expense)
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Collateralized letter of credit
Letter Of Credit Related To New Lease Agreement
Letter of credit related to new lease agreement.
Equity securities
Equity Securities Unrealized Gain
Equity securities unrealized gain.
Accrued expenses and other current liabilities
Accrued Liabilities and Other Liabilities, Total
Accrued Liabilities and Other Liabilities
Weighted-average number of common shares used in computing net loss per share - basic (in shares)
Weighted Average Number of Shares Outstanding, Basic
Net loss per share - diluted (in dollars per share)
Earnings Per Share, Diluted
Product revenue
Product [Member]
Disposal Groups, Including Discontinued Operations [Table]
Disposal Groups, Including Discontinued Operations [Table]
Subsequent events
Subsequent Events [Text Block]
Net loss per share from continuing operations - diluted (in dollars per share)
Income (Loss) from Continuing Operations, Per Diluted Share
Assets:
Assets, Fair Value Disclosure [Abstract]
Comprehensive loss
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Total
Assets, Fair Value Disclosure
Discontinued operations
Discontinued Operations, Policy [Policy Text Block]
Quoted prices in active markets (Level 1)
Fair Value, Inputs, Level 1 [Member]
Cash flows from investing activities:
Investing activities:
Net Cash Provided by (Used in) Investing Activities [Abstract]
Collaborative arrangement revenue
Collaboration Arrangement [Member]
Collaboration arrangement.
Net cash provided by financing activities
Net Cash Provided by (Used in) Financing Activities
Other comprehensive (loss) income:
Other Comprehensive Income (Loss), Net of Tax [Abstract]
Income Tax Disclosure [Abstract]
Income Tax Disclosure [Abstract]
Plans to reduce workforce, as a percent
Restructuring and Related Cost, Number of Positions Eliminated, Period Percent
Entity Small Business
Entity Small Business
Total liabilities and stockholders’ equity
Liabilities and Equity
Other
Other Accrued Liabilities, Current
Investments, Debt and Equity Securities [Abstract]
Investments, Debt and Equity Securities [Abstract]
Net loss per share from continuing operations - basic (in dollars per share)
Income (Loss) from Continuing Operations, Per Basic Share
Accrued clinical and contract research organization costs
Accrued Clinical And Contract Research Organization Costs Current
Accrued clinical and contract research organization costs current.
Deferred revenue, current portion
Contract with Customer, Liability, Current
Fair value measurements
Fair Value Disclosures [Text Block]
Restructuring charges
Restructuring Charges
Accounts payable
Accounts Payable, Current
50 Binney Street Sublease
Fifty Binney Street Sublease [Member]
Fifty Binney Street Sublease.
Exercised (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Service revenue
Service [Member]
Depreciation and amortization
Depreciation, Depletion and Amortization
Additional paid-in capital
Additional Paid in Capital
U.S. government agency securities and treasuries
US Government Agencies Debt Securities [Member]
Lessee, Lease, Description [Table]
Lessee, Lease, Description [Table]
60 Binney Street Lease
Sixty Binney Street Lease [Member]
Sixty Binney street lease.
Recorded Amount of Assets and Liabilities Measured at Fair Value on Recurring Basis
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Liabilities and Stockholders’ Equity
Liabilities and Equity [Abstract]
Net loss per share from discontinued operations - basic (in dollars per share)
Discontinued Operation, Income (Loss) from Discontinued Operation, Net of Tax, Per Basic Share
Accounts payable
Increase (Decrease) in Accounts Payable
Accumulated other comprehensive loss
AOCI Attributable to Parent [Member]
Common stock, shares outstanding (in shares)
Beginning balance (in shares)
Ending balance, shares (in shares)
Common Stock, Shares, Outstanding
Net loss per share
Earnings Per Share [Text Block]
Financial Instruments [Domain]
Financial Instruments [Domain]
Operating expenses:
Operating Expenses [Abstract]
Loss (gain) on equity securities
Equity Securities, FV-NI, Gain (Loss)
Entity Interactive Data Current
Entity Interactive Data Current
Unrealized gains
Debt Securities, Available-for-Sale, Fair Value to Amortized Cost, after Allowance for Credit Loss [Abstract]
Cost of product revenue
Cost of Goods and Services Sold
Revenue:
Revenues [Abstract]
Exercise of stock options
Stock Issued During Period, Value, Stock Options Exercised
Document Period End Date
Document Period End Date
Accrued goods and services
Accrued Goods and Services, Current
Accrued Goods and Services, Current
Change in fair value of contingent consideration
Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability
Marketable securities
Marketable Securities, Current
Entity Central Index Key
Entity Central Index Key
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Shares (in thousands)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Selling, general and administrative
Selling, General and Administrative Expense
Canceled or forfeited (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures and Expirations in Period, Weighted Average Exercise Price
Summary of Property, Plant and Equipment Net
Property, Plant and Equipment [Table Text Block]
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Preferred stock, shares authorized (in shares)
Preferred Stock, Shares Authorized
Income Statement Location
Income Statement Location [Domain]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Debt securities
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax
Debt Securities, Available-for-sale [Table]
Debt Securities, Available-for-sale [Table]
Entity Address, State or Province
Entity Address, State or Province
Loss from operations
Disposal Group, Including Discontinued Operation, Operating Income (Loss)
12 months or greater
Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, 12 Months or Longer
Interest receivable
Interest Receivable
Property, plant and equipment, net
Property, plant and equipment, net
Property, Plant and Equipment, Net
Property, plant and equipment, net
Property, Plant and Equipment Disclosure [Text Block]
Other non-current liabilities
Other Liabilities, Noncurrent
Unrealized losses
Debt Securities, Available-for-sale, Unrealized Loss Position, Accumulated Loss [Abstract]
Cash, cash equivalents and marketable securities
Investments and Cash
Current liabilities:
Liabilities, Current [Abstract]
Marketable securities
Marketable securities:
Marketable Securities
Restructuring Plan [Domain]
Restructuring Plan [Domain]
Trading Symbol
Trading Symbol
Earnings Per Share [Abstract]
Earnings Per Share [Abstract]
Exercisable at end of period (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Net loss per share from discontinued operations - diluted (in dollars per share)
Discontinued Operation, Income (Loss) from Discontinued Operation, Net of Tax, Per Diluted Share
Stock-based compensation
Share-based Payment Arrangement [Text Block]
Total property, plant and equipment
Property, Plant and Equipment, Gross
Significant unobservable inputs (Level 3)
Fair Value, Inputs, Level 3 [Member]
Unrealized gain (loss) on equity securities
Equity Securities, FV-NI, Unrealized Gain (Loss)
Discontinued Operations, Disposed of by Means Other than Sale, Spinoff
Discontinued Operations, Disposed of by Means Other than Sale, Spinoff [Member]
Selling, general and administrative expense related to transition services agreement
Related Party Transaction, Selling, General and Administrative Expenses from Transactions with Related Party
Accounting Policies [Abstract]
Accounting Policies [Abstract]
Total
Debt Securities, Available-for-sale, Unrealized Loss Position, Accumulated Loss
Total revenues
Revenues
Vested and expected to vest at end of period (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Accrued professional fees
Accrued Professional Fees, Current
Marketable securities
Cash, Cash Equivalents, and Marketable Securities [Text Block]
Proceeds from sales of marketable securities
Proceeds from Sale of Debt Securities, Available-for-sale
Laboratory equipment
Laboratory Equipment [Member]
Laboratory Equipment
Document Transition Report
Document Transition Report
Stock options
Employee And Non Employee Stock Option [Member]
Employee and non employee stock option.
Outstanding at beginning of period (in dollars per share)
Outstanding at end of period (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Net loss from continuing operations
Income (Loss) from Continuing Operations, Net of Tax, Attributable to Parent
Common stock, $0.01 par value, 125,000 shares authorized; 71,438 and 71,115 shares issued and outstanding at March 31, 2022 and December 31, 2021, respectively
Common Stock, Value, Issued
Expected weighted-average period of recognition
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unvested balance at beginning of period (in dollars per share)
Unvested balance at end of period (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Basis of presentation
Basis of Accounting, Policy [Policy Text Block]
Commitments and contingencies (Note 9)
Commitments and Contingencies
Stock-based compensation expense
Share-based Payment Arrangement, Expense
Leases
Lessee, Operating Leases [Text Block]
Subsequent Event [Table]
Subsequent Event [Table]
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
Other revenue
Royalty And Other Revenue [Member]
License and royalty.
Entity Emerging Growth Company
Entity Emerging Growth Company
Entity Current Reporting Status
Entity Current Reporting Status
Weighted- average grant date fair value
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]
Lentiviral Vector Manufacturing Facility
Lentiviral Vector Manufacturing Facility [Member]
Lentiviral Vector Manufacturing Facility
Vesting of restricted stock units
Stock Issued During Period Value Vesting Of Restricted Stock Units
Stock issued during period value vesting of restricted stock units.
Investments
Investments [Domain]
Restricted cash included in receivables and other current assets
Restricted Cash, Current
Disposal Group Classification [Axis]
Disposal Group Classification [Axis]
Antidilutive Securities, Name
Antidilutive Securities, Name [Domain]
Proceeds from sale of equity securities
Proceeds from Sale and Maturity of Marketable Securities
Payables and Accruals [Abstract]
Payables and Accruals [Abstract]
Construction-in-progress
Construction in Progress [Member]
Fair value
Debt Securities [Abstract]
Cover page.
Cover [Abstract]
Cash, cash equivalents and restricted cash at beginning of period
Cash, cash equivalents and restricted cash at end of period
Total cash, cash equivalents and restricted cash
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents
Total operating expenses
Costs and Expenses
Interest income, net
Disposal Group, Including Discontinued Operation, Interest Income
Common stock, par value (in dollars per share)
Common Stock, Par or Stated Value Per Share
Current assets:
Assets, Current [Abstract]
Payment for purchase of furniture and equipment, upon lease commencement
Payment for Purchase of Furniture and Equipment, Upon Lease Commencement
Payment for Purchase of Furniture and Equipment, Upon Lease Commencement
Interest income, net
Interest Income (Expense), Nonoperating, Net
Leases [Abstract]
Leases [Abstract]
Cash and cash equivalents
Cash and Cash Equivalents, Fair Value Disclosure
Disposal Group Classification [Domain]
Disposal Group Classification [Domain]
Net loss from discontinued operations
Net loss
Income (Loss) from Discontinued Operations, Net of Tax, Attributable to Parent
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Exercise of stock options (in shares)
Stock option share exercised (in shares)
Exercised (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period
Weighted-average number of common shares used in computing net loss per share - diluted (in shares)
Weighted Average Number of Shares Outstanding, Diluted
Financial Instrument [Axis]
Financial Instrument [Axis]
Selling, general and administrative
Selling, General and Administrative Expenses [Member]
Fair Value, Measurements, Recurring
Fair Value, Recurring [Member]
Other income, net
Disposal Group, Including Discontinued Operation, Other Income
Revenue
Revenue from Contract with Customer, Excluding Assessed Tax
Income taxes
Income Tax Disclosure [Text Block]
Total operating expenses
Disposal Group, Including Discontinued Operation, Operating Expense
Summary of Stock Option Activity Under Plan
Share-based Payment Arrangement, Option, Activity [Table Text Block]
Office equipment
Office Equipment [Member]
Receivables and other current assets
Receivables And Other Current Assets
Receivables and other current assets.
Summary of Revenues , Expenses, Non-cash Items and Capital Expenditures for Discontinued Operations
Disposal Groups, Including Discontinued Operations [Table Text Block]
Common Stock Equivalents Excluded from Calculation of Diluted Net Loss Per Share
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Upfront payment for purchase of furniture and equipment
Upfront Payment For Purchase Of Furniture And Equipment
Upfront payment for purchase of furniture and equipment.
Fair Value Hierarchy and NAV
Fair Value Hierarchy and NAV [Axis]
Excess inventory reserve
Inventory, Excess Valuation Reserves
Inventory, Excess Valuation Reserves
Document Quarterly Report
Document Quarterly Report
Statement of Cash Flows [Abstract]
Statement of Cash Flows [Abstract]
Less than 12 months
Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, Less than 12 Months
Common stock
Common Stock [Member]
Entity Address, Address Line One
Entity Address, Address Line One
Net cash provided by investing activities
Net Cash Provided by (Used in) Investing Activities
Changes in operating assets and liabilities:
Increase (Decrease) in Operating Capital [Abstract]
Less accumulated depreciation and amortization
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Purchase of common stock under ESPP
Stock Issued During Period, Value, Employee Stock Purchase Plan
Loss from operations
Operating Income (Loss)
Cash flows from operating activities:
Operating activities:
Net Cash Provided by (Used in) Operating Activities [Abstract]
Vested (in dollars per share)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Property, Plant and Equipment [Table]
Property, Plant and Equipment [Table]
Consolidation
Consolidation, Policy [Policy Text Block]
Entity Shell Company
Entity Shell Company
Debt Securities, Available-for-sale [Line Items]
Debt Securities, Available-for-sale [Line Items]
Operating lease liability, current portion
Operating Lease, Liability, Current
Debt securities
Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax
Basis of presentation, principles of consolidation and significant accounting policies
Organization, Consolidation and Presentation of Financial Statements Disclosure and Significant Accounting Policies [Text Block]
Total current liabilities
Liabilities, Current
Realized gain (loss) on available-for-sale securities
Debt Securities, Available-for-sale, Realized Gain (Loss)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Document Fiscal Year Focus
Document Fiscal Year Focus
Property, Plant and Equipment [Abstract]
Property, Plant and Equipment [Abstract]
Stock-based compensation expense
Share-based Payment Arrangement, Noncash Expense
Additional paid-in capital
Additional Paid-in Capital [Member]
Cash and cash equivalents
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value
Number of lease renewal options
Lessee, Operating Lease, Number of Renewal Options
Lessee, Operating Lease, Number of Renewal Options
Current Fiscal Year End Date
Current Fiscal Year End Date
Purchases of marketable securities
Payments to Acquire Debt Securities, Available-for-sale
Summary of Marketable Securities Held
Marketable Securities [Table Text Block]
Other (expense) income, net
Other Nonoperating Income (Expense)
Proceed from option share exercised
Proceeds from Stock Plans
Statement [Table]
Statement [Table]
Accrued manufacturing costs
Accrued Manufacturing Costs Current
Accrued manufacturing costs current.
Recent accounting pronouncements
New Accounting Pronouncements, Policy [Policy Text Block]
Issuance of unrestricted stock awards to settle accrued employee compensation
Stock Issued
Purchase of property, plant and equipment
Purchase of property, plant and equipment
Payments to Acquire Property, Plant, and Equipment
Unrecognized stock- based compensation expense
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Maximum
Maximum [Member]
Share-based Payment Arrangement [Abstract]
Share-based Payment Arrangement [Abstract]
Statistical Measurement
Statistical Measurement [Axis]
Total liabilities
Liabilities
Subsequent Event
Subsequent Event [Member]
Summary of Accrued Expenses and Other Current Liabilities
Schedule of Accrued Liabilities [Table Text Block]
Award Type
Award Type [Axis]
Loss before income taxes
Discontinued Operation, Income (Loss) from Discontinued Operation, before Income Tax
Granted (in dollars per share)
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Cash flows from financing activities:
Net Cash Provided by (Used in) Financing Activities [Abstract]
Goodwill
Goodwill
Total stockholders’ equity
Beginning balance
Ending balance
Stockholders' Equity Attributable to Parent
Increase in shares authorized (in shares)
Share-based Compensation Arrangement By Share-based Payment Award, Increase In Shares Authorized
Share-based Compensation Arrangement By Share-based Payment Award, Increase In Shares Authorized
Less than 12 months
Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss
Common stock, shares issued (in shares)
Common Stock, Shares, Issued
Preferred stock, shares issued (in shares)
Preferred Stock, Shares Issued
City Area Code
City Area Code
Net assets transferred to 2seventy bio
Disposal Group, Including Discontinued Operation, Net Assets Transferred
Disposal Group, Including Discontinued Operation, Net Assets Transferred
Description of the business
Nature of Operations [Text Block]
Adjustments to reconcile net loss to net cash used in operating activities:
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Increased number of issuance of awards under the 2013 Plan (in shares)
Share-based Compensation Arrangement by Share-based Payment Award, Options, Other Increases (Decreases) in Period
Subsequent Event Type [Axis]
Subsequent Event Type [Axis]
Entity Address, City or Town
Entity Address, City or Town
Conversion ratio
Common Stock, Convertible, Conversion Ratio
Common Stock, Convertible, Conversion Ratio
12 months or greater
Debt Securities, Available-for-sale, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss
Stockholders’ equity:
Stockholders' Equity Attributable to Parent [Abstract]
Supplemental cash flow disclosures from investing and financing activities:
Noncash Investing and Financing Items [Abstract]