Condensed Consolidated Statements of Cash Flows (unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Cash flows from operating activities:
Net loss	$ (122,152)	$ (205,808)
Adjustments to reconcile net loss to net cash used in operating activities:
Change in fair value of contingent consideration	0	369
Depreciation and amortization	1,014	5,360
Stock-based compensation expense	12,390	42,527
Loss (gain) on equity securities	2,508	(28,372)
Excess inventory reserve	7,519	0
Other non-cash items	189	2,513
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(13,059)	(16,082)
Operating lease right-of-use assets	6,517	8,098
Accounts payable	2,467	67
Accrued expenses and other liabilities	(16,561)	(2,693)
Operating lease liabilities	(6,128)	(9,306)
Net cash used in operating activities	(125,296)	(203,327)
Cash flows from investing activities:
Purchase of property, plant and equipment	(857)	(7,626)
Purchases of marketable securities	0	(53,200)
Proceeds from maturities of marketable securities	70,783	350,860
Proceeds from sales of marketable securities	0	31,318
Net cash provided by investing activities	69,926	321,352
Cash flows from financing activities:
Proceeds from exercise of stock options and ESPP contributions	9	3,796
Net cash provided by financing activities	9	3,796
(Decrease) increase in cash, cash equivalents and restricted cash	(55,361)	121,821
Cash, cash equivalents and restricted cash at beginning of period	206,693	373,728
Cash, cash equivalents and restricted cash at end of period	151,332	495,549
Reconciliation of cash, cash equivalents and restricted cash:
Cash and cash equivalents	106,260	439,714
Restricted cash included in receivables and other current assets	1,822	1,330
Restricted cash included in restricted cash and other non-current assets	43,250	54,505
Total cash, cash equivalents and restricted cash	151,332	495,549
Supplemental cash flow disclosures from investing and financing activities:
Purchases of property, plant and equipment included in accounts payable and accrued expenses	2,134	2,238
Right-of-use assets obtained in exchange for operating lease liabilities	26,882	22,049
Issuance of unrestricted stock awards to settle accrued employee compensation	$ 0	$ 12,013