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Net loss per share (Tables)
3 Months Ended
Mar. 31, 2022
Earnings Per Share [Abstract]  
Common Stock Equivalents Excluded from Calculation of Diluted Net Loss Per Share The following common stock equivalents were excluded from the calculation of diluted net loss per share for the periods indicated because including them would have had an anti-dilutive effect (in thousands):
For the three months ended March 31,
20222021
Outstanding stock options (1)
5,645 6,458 
Restricted stock units (1)
4,053 2,073 
ESPP shares and other264 884 
9,962 9,415 
(1) Outstanding stock options and restricted stock units include awards outstanding to employees of 2seventy bio for shares of the Company's common stock.