Stock-based compensation (Tables)

3 Months Ended

Mar. 31, 2022

Share-based Payment Arrangement [Abstract]

Summary of Stock-Based Compensation Expense by Award Type

Stock-based compensation expense recognized by award type is included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands):

	For the three months ended March 31,
	2022		2021(1)
Stock options	$	5,260	$	16,426
Restricted stock units	7,034		10,217
Employee stock purchase plan and other	96		4,651
	$	12,390	$	31,294

(1) Prior period amounts have been retrospectively adjusted to reflect the effects of the Separation.

Schedule of Stock-Based Compensation Expense by Classification

Stock-based compensation expense by classification included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands): 

	For the three months ended March 31,
	2022		2021(1)
Research and development	$	6,555	$	12,390
Selling, general and administrative	5,835		18,904
	$	12,390	$	31,294

(1) Prior period amounts have been retrospectively adjusted to reflect the effects of the Separation.

Summary of Stock Option Activity Under Plan

The following table summarizes the stock option activity under the Company’s equity award plans:

	Shares (in thousands)	Weighted- average exercise price per share
Outstanding at December 31, 2021	3,586	$	39.23
Granted	890	$	7.79
Exercised	(1)	$	1.04
Canceled or forfeited	(735)	$	58.27
Outstanding at March 31, 2022	3,740	$	29.14
Exercisable at March 31, 2022	1,406	$	52.80
Vested and expected to vest at March 31, 2022	3,740	$	29.14

Summary of Restricted Common Stock Awards

The following table summarizes the restricted stock unit activity under the Company’s equity award plans:

	Shares (in thousands)	Weighted- average grant date fair value
Unvested at December 31, 2021	3,193	$	16.21
Granted	1,291	$	7.85
Vested	(238)	$	26.67
Forfeited	(340)	$	14.79
Unvested at March 31, 2022	3,906	$	12.96