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Discontinued operations (Tables)
3 Months Ended
Mar. 31, 2022
Discontinued Operations and Disposal Groups [Abstract]  
Summary of Revenues , Expenses, Non-cash Items and Capital Expenditures for Discontinued Operations The following table summarizes revenue and expenses of the discontinued operations for the three months ended March 31, 2021 (in thousands):
Three months ended March 31, 2021
Revenue:
Service revenue$5,918 
Collaborative arrangement revenue1,519 
Royalty and other revenue4,463 
Total revenues11,900 
Operating expenses:
Research and development71,635 
Selling, general and administrative23,305 
Cost of royalty and other revenue1,705 
Change in fair value of contingent consideration369 
Total operating expenses97,014 
Loss from operations(85,114)
Interest income, net355 
Other income, net455 
Loss before income taxes(84,304)
Income tax benefit (expense)— 
Net loss$(84,304)
The following table summarizes the significant non-cash items and capital expenditures of the discontinued operations that are included in the condensed consolidated statements of cash flows for the three months ended March 31, 2021 (in thousands):

Three months ended March 31, 2021
Operating activities:
Change in fair value of contingent consideration$369 
Depreciation and amortization3,800 
Stock-based compensation expense11,181 
Investing activities:
Purchase of property, plant and equipment$(6,173)
Supplemental cash flow disclosures:
Purchases of property, plant and equipment included in accounts payable and accrued expenses$1,954