Accrued expenses and other current liabilities - Summary of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Payables and Accruals [Abstract]
Employee compensation	$ 41,095	$ 41,192
Accrued goods and services	24,273	14,855
Accrued clinical and contract research organization costs	17,769	20,912
Accrued manufacturing costs	15,722	15,763
Accrued professional fees	1,665	1,541
Deferred revenue, current portion	2,282	1,500
Other	1,152	2,427
Total accrued expenses and other current liabilities	$ 103,958	$ 98,190