Property, plant and equipment, net - Summary of Property, Plant and Equipment Net (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Property, Plant and Equipment [Line Items]
Total property, plant and equipment	$ 30,112	$ 35,514
Less accumulated depreciation and amortization	(20,406)	(18,141)
Property, plant and equipment, net	9,706	17,373
Laboratory equipment
Property, Plant and Equipment [Line Items]
Total property, plant and equipment	29,061	27,146
Computer equipment and software
Property, Plant and Equipment [Line Items]
Total property, plant and equipment	421	447
Office equipment
Property, Plant and Equipment [Line Items]
Total property, plant and equipment	117	1,077
Leasehold improvements
Property, Plant and Equipment [Line Items]
Total property, plant and equipment	12	5,949
Construction-in-progress
Property, Plant and Equipment [Line Items]
Total property, plant and equipment	$ 501	$ 895