Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenue:
Total revenues	$ 3,662	$ 0	$ 0
Operating expenses:
Research and development	319,946	319,309	327,119
Selling, general and administrative	209,969	239,950	235,844
Restructuring expense	25,801	0	0
Total operating expenses	594,573	559,259	562,963
Loss from operations	(590,911)	(559,259)	(562,963)
Interest income, net	879	5,770	17,380
Other income (expense), net	27,652	(6,881)	(9,984)
Loss before income taxes	(562,380)	(560,370)	(555,567)
Income tax (expense) benefit	(258)	(686)	545
Net loss from continuing operations	(562,638)	(561,056)	(555,022)
Net income (loss) from discontinued operations	(256,740)	(57,639)	(234,586)
Net loss	$ (819,378)	$ (618,695)	$ (789,608)
Net loss per share from continuing operations - basic (in dollars per share)	$ (8.16)	$ (9.02)	$ (10.06)
Net loss per share from continuing operations - diluted (in dollars per share)	(8.16)	(9.02)	(10.06)
Net loss per share from discontinued operations - basic (in dollars per share)	(3.73)	(0.93)	(4.25)
Net loss per share from discontinued operations - diluted (in dollars per share)	(3.73)	(0.93)	(4.25)
Net loss per share applicable to common stockholders - basic (in dollars per share)	(11.89)	(9.95)	(14.31)
Net loss per share applicable to common stockholders - diluted (in dollars per share)	$ (11.89)	$ (9.95)	$ (14.31)
Weighted-average number of common shares used in computing net loss per share - basic and diluted (in shares)	68,910	62,178	55,191
Other comprehensive income (loss):
Other comprehensive income (loss)	$ 2,364	$ (3,612)	$ 1,734
Comprehensive loss	(817,014)	(622,307)	(787,874)
Product revenue
Revenue:
Revenue	2,850	0	0
Operating expenses:
Cost of product revenue	38,857	0	0
Other revenue
Revenue:
Revenue	$ 812	$ 0	$ 0