Net loss per share (Tables)

12 Months Ended

Dec. 31, 2021

Earnings Per Share [Abstract]

Common Stock Equivalents Excluded from Calculation of Diluted Net Loss Per Share

The following common stock equivalents were excluded from the calculation of diluted net loss per share for the periods indicated because including them would have had an anti-dilutive effect (in thousands):

	Year ended December 31,
	2021	2020	2019
Outstanding stock options (1)	5,534	6,262	5,483
Restricted stock units (1)	3,427	1,495	1,127
ESPP shares and other	—	326	19
	8,961	8,083	6,629

(1) Outstanding stock options and restricted stock units include awards outstanding to employees of 2seventy bio.