Property, plant and equipment, net - Summary of Property, Plant and Equipment Net (Detail) - USD ($) $ in Thousands	Sep. 30, 2021	Dec. 31, 2020
Property, Plant and Equipment [Line Items]
Total property, plant and equipment	$ 104,512	$ 213,891
Less accumulated depreciation and amortization	(58,767)	(51,060)
Property, plant and equipment, net	45,745	162,831
Land
Property, Plant and Equipment [Line Items]
Total property, plant and equipment	0	1,210
Building
Property, Plant and Equipment [Line Items]
Total property, plant and equipment	0	15,745
Computer equipment and software
Property, Plant and Equipment [Line Items]
Total property, plant and equipment	5,699	6,950
Office equipment
Property, Plant and Equipment [Line Items]
Total property, plant and equipment	6,686	7,665
Laboratory equipment
Property, Plant and Equipment [Line Items]
Total property, plant and equipment	59,673	55,521
Leasehold improvements
Property, Plant and Equipment [Line Items]
Total property, plant and equipment	31,579	34,286
Construction-in-progress
Property, Plant and Equipment [Line Items]
Total property, plant and equipment	$ 875	$ 92,514