Condensed Consolidated Statements of Operations and Comprehensive Loss (unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Revenue:
Collaborative arrangement revenue	$ 14,831	$ 2,422	$ 18,020	$ 114,398
Total revenues	22,677	19,273	42,943	240,026
Operating expenses:
Research and development	131,427	140,431	429,614	450,862
Selling, general and administrative	68,277	68,046	229,708	209,922
Share of collaboration loss	0	0	10,071	0
Cost of royalty and other revenue	19,704	1,318	37,286	3,897
Restructuring expense	20,175	0	24,800	0
Change in fair value of contingent consideration	48	(828)	464	(5,591)
Total operating expenses	239,631	208,967	731,943	659,090
Loss from operations	(216,954)	(189,694)	(689,000)	(419,064)
Interest income, net	319	1,964	1,468	10,258
Other income (expense), net	(294)	(6,686)	23,375	(9,582)
Loss before income taxes	(216,929)	(194,416)	(664,157)	(418,388)
Income tax benefit (expense)	113	(329)	(169)	(433)
Net loss	$ (216,816)	$ (194,745)	$ (664,326)	$ (418,821)
Net loss per share - basic: (in dollars per share)	$ (3.16)	$ (2.94)	$ (9.81)	$ (6.89)
Net loss per share - diluted: (in dollars per share)	$ (3.16)	$ (2.94)	$ (9.81)	$ (6.89)
Weighted-average number of common shares used in computing net loss per share - basic: (in shares)	68,621	66,251	67,701	60,762
Weighted-average number of common shares used in computing net loss per share - diluted: (in shares)	68,621	66,251	67,701	60,762
Other comprehensive loss:
Other comprehensive loss, net of tax benefit (expense) of $0.0 million and $0.1 million for the three months ended September 30, 2021 and 2020, respectively, and $0.0 million for the nine months ended September 30, 2021 and 2020.	$ (129)	$ (1,823)	$ (401)	$ (2,330)
Comprehensive loss	(216,945)	(196,568)	(664,727)	(421,151)
Service revenue
Revenue:
Revenue	6,312	13,352	17,544	108,542
Royalty and other revenue
Revenue:
Revenue	$ 1,534	$ 3,499	$ 7,379	$ 17,086