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Stock-based compensation (Tables)
 9 Months Ended
Sep. 30, 2021
Share-based Payment Arrangement [Abstract]  
Summary of Stock-Based Compensation Expense by Award Type Stock-based compensation expense by award type included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands):
For the three months ended September 30,For the nine months ended September 30,

2021202020212020
Stock options
13,688 22,723 51,671 73,236 
Restricted stock units
10,335 11,935 33,601 37,931 
Employee stock purchase plan and other4,315 4,160 16,591 12,473 
28,338 38,818 101,863 123,640 
Schedule of Stock-Based Compensation Expense by Classification Stock-based compensation expense by classification included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands): 
For the three months ended September 30,For the nine months ended September 30,
2021202020212020
Research and development$13,688 $18,837 $49,324 $58,204 
Selling, general and administrative14,650 19,981 52,539 65,436 
$28,338 $38,818 $101,863 $123,640 
Summary of Stock Option Activity Under Plan The following table summarizes the stock option activity under the Company’s equity award plans:
Shares
(in thousands)
Weighted-
average
exercise price
per share
Outstanding at December 31, 20206,262 $105.02 
Granted
1,188 $27.85 
Exercised
(219)$6.82 
Canceled, forfeited, or expired
(1,557)$104.89 
Outstanding at September 30, 20215,674 $92.68 
Exercisable at September 30, 20213,527 $111.09 
Vested and expected to vest at September 30, 20215,373 $92.68 
Summary of Restricted Common Stock Awards The following table summarizes the restricted stock unit activity under the Company’s equity award plans:
Shares
(in thousands)		Weighted-
average
grant date
fair value
Unvested balance at December 31, 20201,495 $102.34 
Granted
3,268 $26.81 
Vested
(501)$114.58 
Forfeited
(724)$60.33 
Unvested balance at September 30, 20213,538 $39.43