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Accrued expenses and other current liabilities
9 Months Ended
Sep. 30, 2021
Payables and Accruals [Abstract]  
Accrued expenses and other current liabilities Accrued expenses and other current liabilitiesAccrued expenses and other current liabilities consist of the following (in thousands):
As of September 30, 2021As of December 31, 2020
Employee compensation$95,505 $55,802 
Manufacturing costs21,809 22,571 
Clinical and contract research organization costs19,017 23,766 
Collaboration costs28,031 20,004 
Property, plant and equipment618 789 
License and milestone fees467 278 
Professional fees2,549 1,541 
Other35,794 20,655 
Accrued expenses and other current liabilities$203,790 $145,406 
Accrued employee compensation includes severance costs associated with the Company's orderly wind down of its European operations. As of September 30, 2021, the Company had accrued expenses of $19.7 million related to these restructuring costs. Please refer to Note 16, Reduction in Workforce, for further discussion.