Accrued expenses and other current liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2021	Dec. 31, 2020
Payables and Accruals [Abstract]
Employee compensation	$ 45,916	$ 55,802
Manufacturing costs	24,726	22,571
Clinical and contract research organization costs	23,377	23,766
Collaboration research costs	23,679	20,004
Property, plant and equipment	1,543	789
License and milestone fees	303	278
Professional fees	1,993	1,541
Other	25,254	20,655
Accrued expenses and other current liabilities	$ 146,791	$ 145,406