Condensed Consolidated Statements of Operations and Comprehensive Loss (unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020
Revenue:
Collaborative arrangement revenue	$ 1,519	$ 2,302
Total revenues	12,794	21,863
Operating expenses:
Research and development	154,478	154,123
Selling, general and administrative	86,874	73,248
Cost of royalty and other revenue	2,281	1,025
Change in fair value of contingent consideration	369	(3,108)
Total operating expenses	244,002	225,288
Loss from operations	(231,208)	(203,425)
Interest income, net	710	5,355
Other income (expense), net	24,756	(4,447)
Loss before income taxes	(205,742)	(202,517)
Income tax expense	(66)	(94)
Net loss	$ (205,808)	$ (202,611)
Net loss per share - basic and diluted: (in dollars per share)	$ (3.07)	$ (3.64)
Weighted-average number of common shares used in computing net loss per share - basic and diluted: (in shares)	66,976	55,590
Other comprehensive income (loss):
Other comprehensive income (loss), net of tax benefit (expense) of $0.0 million for the three months ended March 31, 2021 and 2020	$ 56	$ (906)
Comprehensive loss	(205,752)	(203,517)
Service revenue
Revenue:
Revenue	5,918	16,833
Royalty and other revenue
Revenue:
Revenue	$ 5,357	$ 2,728