Fair value measurements - Recorded Amount of Assets and Liabilities Measured at Fair Value on Recurring Basis (Detail) - USD ($) $ in Thousands	Mar. 31, 2021	Dec. 31, 2020
Assets:
Marketable securities:	$ 653,837	$ 956,437
Equity securities	2,707	5,653
Fair Value, Measurements, Recurring
Assets:
Cash and cash equivalents	439,714	317,705
Equity securities	2,707	5,653
Total	1,093,551	1,274,142
Liabilities:
Contingent consideration	1,878	1,509
Total	1,878	1,509
Fair Value, Measurements, Recurring | U.S. government agency securities and treasuries
Assets:
Marketable securities:	429,279	675,271
Fair Value, Measurements, Recurring | Corporate bonds
Assets:
Marketable securities:	142,896	197,563
Fair Value, Measurements, Recurring | Commercial paper
Assets:
Marketable securities:	78,955	77,950
Fair Value, Measurements, Recurring | Quoted prices in active markets (Level 1)
Assets:
Cash and cash equivalents	410,715	317,705
Equity securities	2,707	5,653
Total	413,422	323,358
Liabilities:
Contingent consideration	0	0
Total	0	0
Fair Value, Measurements, Recurring | Quoted prices in active markets (Level 1) | U.S. government agency securities and treasuries
Assets:
Marketable securities:	0	0
Fair Value, Measurements, Recurring | Quoted prices in active markets (Level 1) | Corporate bonds
Assets:
Marketable securities:	0	0
Fair Value, Measurements, Recurring | Quoted prices in active markets (Level 1) | Commercial paper
Assets:
Marketable securities:	0	0
Fair Value, Measurements, Recurring | Significant other observable inputs (Level 2)
Assets:
Cash and cash equivalents	28,999	0
Equity securities	0	0
Total	680,129	950,784
Liabilities:
Contingent consideration	0	0
Total	0	0
Fair Value, Measurements, Recurring | Significant other observable inputs (Level 2) | U.S. government agency securities and treasuries
Assets:
Marketable securities:	429,279	675,271
Fair Value, Measurements, Recurring | Significant other observable inputs (Level 2) | Corporate bonds
Assets:
Marketable securities:	142,896	197,563
Fair Value, Measurements, Recurring | Significant other observable inputs (Level 2) | Commercial paper
Assets:
Marketable securities:	78,955	77,950
Fair Value, Measurements, Recurring | Significant unobservable inputs (Level 3)
Assets:
Cash and cash equivalents	0	0
Equity securities	0	0
Total	0	0
Liabilities:
Contingent consideration	1,878	1,509
Total	1,878	1,509
Fair Value, Measurements, Recurring | Significant unobservable inputs (Level 3) | U.S. government agency securities and treasuries
Assets:
Marketable securities:	0	0
Fair Value, Measurements, Recurring | Significant unobservable inputs (Level 3) | Corporate bonds
Assets:
Marketable securities:	0	0
Fair Value, Measurements, Recurring | Significant unobservable inputs (Level 3) | Commercial paper
Assets:
Marketable securities:	$ 0	$ 0