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Stock-based compensation (Tables)
 3 Months Ended
Mar. 31, 2021
Share-based Payment Arrangement [Abstract]  
Summary of Stock-Based Compensation Expense by Award Type Stock-based compensation expense by award type included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands):
For the three months ended March 31,

20212020
Stock options
$20,659 $24,440 
Restricted stock units
14,733 11,853 
Employee stock purchase plan and other7,082 — 
$42,474 $36,293 
Schedule of Stock-Based Compensation Expense by Classification
Stock-based compensation expense by classification included within the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands): 
For the three months ended March 31,
20212020
Research and development$19,868 $16,269 
Selling, general and administrative22,606 20,024 
$42,474 $36,293 
Summary of Stock Option Activity Under Plan
The following table summarizes the stock option activity under the Company’s equity award plans:
Shares
(in thousands)
Weighted-
average
exercise price
per share
Outstanding at December 31, 20206,262 $105.02 
Granted
671 $29.17 
Exercised
(207)$5.88 
Canceled, forfeited, or expired
(268)$110.62 
Outstanding at March 31, 20216,458 $100.08 
Exercisable at March 31, 20213,829 $111.17 
Vested and expected to vest at March 31, 20216,458 $100.08 
Summary of Restricted Common Stock Awards The following table summarizes the restricted stock unit activity under the Company’s equity award plans:
Shares
(in thousands)		Weighted-
average
grant date
fair value
Unvested balance at December 31, 20201,495 $102.34 
Granted
990 $29.17 
Vested
(294)$108.85 
Forfeited
(118)$84.63 
Unvested balance at March 31, 20212,073 $67.48