Property, plant and equipment, net

3 Months Ended

Mar. 31, 2021

Property, Plant and Equipment [Abstract]

Property, plant and equipment, net, consists of the following (in thousands):


	As of March 31, 2021		As of December 31, 2020
Land	$	1,210	$	1,210
Building	88,591		15,745
Computer equipment and software	6,919		6,950
Office equipment	7,633		7,665
Laboratory equipment	66,600		55,521
Leasehold improvements	34,104		34,286
Construction-in-progress	14,939		92,514
Total property, plant and equipment	219,996		213,891
Less accumulated depreciation and amortization	(54,798)		(51,060)
Property, plant and equipment, net	$	165,198	$	162,831

North Carolina manufacturing facility

In November 2017, the Company acquired a manufacturing facility in Durham, North Carolina for the future manufacture of lentiviral vector for the Company’s gene therapies. As of March 31, 2021, the majority of the facility has been placed into service. The remainder of the facility is still in process of qualification, which is required for the facility to be ready for its intended use. Construction-in-progress as of March 31, 2021 and December 31, 2020 includes $14.2 million and $91.1 million, respectively, related to the North Carolina manufacturing facility.