Accrued expenses and other current liabilities - Summary of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019
Payables and Accruals [Abstract]
Employee compensation	$ 55,802	$ 44,679
Manufacturing costs	22,571	23,126
Clinical and contract research organization costs	23,766	16,799
Collaboration research costs	20,004	27,142
Property, plant, and equipment	789	2,354
License and milestone fees	278	300
Professional fees	1,541	1,827
Other	20,655	25,329
Total accrued expenses and other current liabilities	$ 145,406	$ 141,556