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Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
3 Months Ended
Mar. 31, 2020
Mar. 31, 2019
Revenue:    
Collaborative arrangement revenue $ 2,302 $ 1,966
Total revenues 21,863 12,471
Operating expenses:    
Research and development 154,123 122,640
Selling, general and administrative 73,248 60,279
Cost of royalty revenue 1,025 430
Change in fair value of contingent consideration (3,108) 296
Total operating expenses 225,288 183,645
Loss from operations (203,425) (171,174)
Interest income, net 5,355 10,102
Other expense, net (4,447) (3,389)
Loss before income taxes (202,517) (164,461)
Income tax (expense) benefit (94) 15
Net loss $ (202,611) $ (164,446)
Net loss per share - basic and diluted: $ (3.64) $ (2.99)
Weighted-average number of common shares used in computing net loss per share - basic and diluted: 55,590 54,957
Other comprehensive (loss) income:    
Other comprehensive (loss) income, net of tax expense of $0.0 million and $0.4 million for the three months ended March 31, 2020 and 2019, respectively $ (906) $ 1,835
Total other comprehensive (loss) income (906) 1,835
Comprehensive loss (203,517) (162,611)
Service revenue    
Revenue:    
Revenue 16,833 9,211
Royalty revenue    
Revenue:    
Revenue $ 2,728 $ 1,294