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Collaborative arrangements - Summary of Revenue Recognized or Expense Incurred (Detail) - USD ($)
$ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Research and development                 $ 582,413 $ 448,589 $ 273,040
Revenue $ 9,997 $ 8,910 $ 13,296 $ 12,471 $ 19,243 $ 11,528 $ 7,851 $ 15,957 44,674 54,579 35,427
Bristol-Myers Squibb | U.S. | License and manufacturing services                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer                 0 6,255  
Bristol-Myers Squibb | U.S. | License and manufacturing services | Balances Without Adoption of Topic 606                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer                     4,905
Bristol-Myers Squibb | U.S. | Ide-cel license and manufacturing services | License and manufacturing services                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Research and development                 32,415 8,689  
Bristol-Myers Squibb | U.S. | Ide-cel license and manufacturing services | License and manufacturing services | Balances Without Adoption of Topic 606                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Research and development                     3,037
Bristol-Myers Squibb | Outside of U.S. | Ide-cel license and manufacturing services | License and manufacturing services                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Revenue                 $ 25,522 $ 35,900  
Bristol-Myers Squibb | Outside of U.S. | Ide-cel license and manufacturing services | License and manufacturing services | Balances Without Adoption of Topic 606                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Revenue                     $ 10,372