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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
shares in Thousands, $ in Thousands
12 Months Ended
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Revenue:      
Revenue $ 44,674 $ 54,579 $ 35,427
Operating expenses:      
Research and development 582,413 448,589 273,040
Selling, general and administrative 271,362 174,129 93,550
Cost of license and royalty revenue 2,978 885 1,527
Change in fair value of contingent consideration 2,747 2,999 (525)
Total operating expenses 859,500 626,602 367,592
Loss from operations (814,826) (572,023) (332,165)
Interest income (expense), net 34,761 14,624 (2,001)
Other (expense) income, net (10,088) 1,961 (1,267)
Loss before income taxes (790,153) (555,438) (335,433)
Income tax benefit (expense) 545 (187) (210)
Net loss $ (789,608) $ (555,625) $ (335,643)
Net loss per share - basic and diluted (in dollars per share) $ (14.31) $ (10.68) $ (7.71)
Weighted-average number of common shares used in computing net loss per share - basic and diluted (in shares) 55,191 52,032 43,535
Other comprehensive income (loss):      
Other comprehensive income $ 1,734 $ 578 $ (3,056)
Comprehensive loss (787,874) (555,047) (338,699)
Other comprehensive income (loss) tax expense 1,200 400 0
Collaboration revenue      
Revenue:      
Revenue 36,469 52,353 22,207
License and royalty revenue      
Revenue:      
Revenue $ 8,205 $ 2,226 $ 13,220