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Property, plant and equipment, net
 12 Months Ended
Dec. 31, 2019
Property, Plant and Equipment [Abstract]  
Property, plant and equipment, net Property, plant and equipment, net
Property, plant and equipment, net, consists of the following (in thousands):
As of December 31,
20192018
Land$1,210  $1,210  
Building15,664  180,094  
Computer equipment and software6,947  6,365  
Office equipment7,599  5,584  
Laboratory equipment44,560  35,693  
Leasehold improvements33,788  183  
Construction-in-progress77,981  46,669  
Total property, plant and equipment187,749  275,798  
Less accumulated depreciation and amortization(36,573) (29,176) 
Property, plant and equipment, net  $151,176  $246,622  
Depreciation and amortization expense related to property, plant and equipment was $13.4 million, $13.4 million, and $9.8 million for the years ended December 31, 2019, 2018, and 2017, respectively.
North Carolina manufacturing facility
In November 2017, the Company acquired a manufacturing facility in Durham, North Carolina for the future manufacture of lentiviral vector for the Company’s gene therapies. As of December 31, 2019, a portion of the facility has been placed into service and the remainder of the facility is still in process of construction.  Construction-in-progress as of December 31, 2019, and 2018, includes $74.2 million and $40.4 million, respectively, related to the North Carolina manufacturing facility.
60 Binney Street Lease
As a result of the adoption of ASU 2016-02, the Company de-recognized $156.0 million of the building asset and $6.7 million of accumulated depreciation related to its corporate headquarters at 60 Binney Street. Prior to the adoption of ASU 2016-02, the Company classified leasehold improvements associated with the 60 Binney Street building as building assets. Subsequent to the adoption of ASU 2016-02, the leasehold improvements owned by the Company associated with the 60 Binney Street building are classified as leasehold improvements. Please refer to Note 2, Summary of significant accounting policies and basis of presentation, and Note 8, Leases, for further information.