License agreements, research collaborations and development agreements (Details Textual)	3 Months Ended
	Mar. 31, 2018 USD ($) Agreement	Mar. 31, 2017 USD ($)
License Agreements Research Collaborations And Development Agreements [Line Items]
Royalty expense	$ 62,500	$ 69,245
Annual future minimum royalty payments due	$ 250,000
FISH Product Line [Member]
License Agreements Research Collaborations And Development Agreements [Line Items]
Number of license agreements | Agreement	1