XML 63 R40.htm IDEA: XBRL DOCUMENT v3.6.0.2
Stockholders' Equity (Details Textual) - USD ($)
1 Months Ended 2 Months Ended 3 Months Ended 12 Months Ended
Mar. 24, 2017
Feb. 22, 2017
Dec. 31, 2016
Sep. 13, 2016
Jun. 27, 2016
May 19, 2016
Jul. 14, 2015
May 08, 2015
Jul. 31, 2016
Jul. 31, 2015
Jun. 30, 2016
Dec. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Common stock, shares authorized     200,000,000                 200,000,000 200,000,000 200,000,000
Common stock, shares issued     25,304,270                 12,547,684 25,304,270 12,547,684
Common stock, shares outstanding     25,304,270                 12,547,684 25,304,270 12,547,684
Preferred stock, shares authorized     10,000,000                 10,000,000 10,000,000 10,000,000
Preferred stock, shares issued     0                 0 0 0
Preferred stock, shares outstanding     0                 0 0 0
Proceeds from issuance of common stock, net of issuance costs                         $ 4,405,973 $ 17,366,620
Proceeds from issuance of private placement net         $ 9,500,000               9,460,749 0
Convertible preferred stock, beneficial conversion feature recognized as deemed dividend                 $ 332,550          
Proceeds from issuance of units under initial public offering gross               $ 17,100,000            
Proceeds from issuance of units under initial public offering net               $ 12,100,000            
Stock and warrants issued during period shares initial public offering purchase price per unit               $ 6.00            
Share-based compensation, tax benefit from compensation expense                         0  
Employee service share-based compensation, non-vested awards, compensation cost not yet recognized, total     $ 2,200,000                   $ 2,200,000  
Employee service share-based compensation, non-vested awards, compensation cost not yet recognized, period for recognition                         1 year 2 months 1 day  
Share-based compensation arrangement by share-based payment award, options, vested in period, fair value                         $ 1,088,978 $ 1,140,079
Share-based compensation arrangement by share-based payment award, options, grants in period, gross                         1,463,650 1,961,637
Restricted Stock Units [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Share-based compensation arrangement by share-based payment award, equity instruments other than options, grants in period                       75,000    
Share-based compensation arrangement by share-based payment award, equity instruments other than options, grants in period, weighted average grant date fair value                       $ 1.70 $ 1.70  
Share-based compensation arrangement by share-based payment award, equity instruments other than options, non-vested, outstanding     18,750                   18,750  
Share-based compensation arrangement by share-based payment award, equity instruments other than options, vested in period                         16,666  
Share-based compensation arrangement by share-based payment award, equity instruments other than options, forfeited in period                         39,584  
2015 Plan [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Share-based compensation arrangement by share-based payment award, number of shares authorized     1,355,000                   1,355,000  
Share-based compensation arrangement by share-based payment award, description                         the number of shares that have been authorized for issuance under the 2015 Plan will be automatically increased on the first day of each fiscal year beginning on January 1, 2016 and ending on (and including) January 1, 2025, in an amount equal to the lesser of (1) 4% of the outstanding shares of common stock on the last day of the immediately preceding fiscal year, or (2) another lesser amount determined by the Company’s Board of Directors.  
Share-based compensation arrangement by share-based payment award, number of shares available for grant     669,651                   669,651  
Share-based compensation arrangement by share-based payment award, common stock percentage                         4.00%  
Demand Notes Payable [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Debt conversion, converted instrument, amount               $ 2,100,000            
May 2016 Warrant [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Class of warrant or right, exercise price of warrants or rights           $ 1.3125                
Warrant expiration period           5 years                
Expiration date of warrants issued                         May 18, 2021  
June 2016 Warrant [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Class of warrant or right, exercise price of warrants or rights         $ 1.3125                  
Warrant expiration period         5 years                  
Expiration date of warrants issued                         May 18, 2021  
Common Stock [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Conversion of stock, shares issued                 2,309,428          
Stock and warrants issued in conjunction with initial public offering               2,850,000            
Warrants issued during period on exercise of over allotment option shares               422,500            
Proceeds from issuance of warrants               $ 4,225            
Underwriting discounts commissions and offering expenses               $ 2,900,000            
Convertible preferred stock, shares issued upon conversion               7,374,852       7,374,852   7,374,852
Common Stock [Member] | Merck GHI [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Stock issued during period, shares, new issues             1,136,364     1,136,364        
Proceeds from issuance of common stock, net of issuance costs             $ 5,000,000              
Non-voting Convertible Preferred Stock [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Conversion of stock, shares converted                 2,309,428          
At the Market Offering [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Stock issued during period, value, new issues                         $ 4,405,973  
At the Market Offering [Member] | Common Stock [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Stock issued during period, value, new issues                         $ 36,199  
Stock issued during period, shares, new issues                         3,619,863  
Private Placement [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Stock issued during period, value, new issues                         $ 9,460,749  
Class of warrant or right, number of securities called by each warrant or right         0.75                  
Class of warrant or right, number of securities called by warrants or rights         6,790,169           6,790,169      
Class of warrant or right, exercise price of warrants or rights         $ 1.14           $ 1.14      
Sale of stock, description of transaction                         (i) one share of common stock and a detachable stock purchase warrant to purchase an additional 0.75 shares of common stock, or (ii) one share of non-voting convertible preferred stock and a detachable stock purchase warrant to purchase an additional 0.75 shares of common stock, at a price of $1.14 per unit.  
Proceeds from issuance of private placement net                     $ 9,500,000      
Private Placement [Member] | Common Stock [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Stock issued during period, value, new issues                         $ 67,441  
Stock issued during period, shares, new issues         6,744,127           6,744,127   6,744,127  
Private Placement [Member] | Non-voting Convertible Preferred Stock [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Stock issued during period, shares, new issues         2,309,428           2,309,428      
IPO [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Stock issued during period, value, new issues                           $ 12,129,133
Debt conversion, converted instrument, shares issued               350,000            
Debt conversion, converted instrument, amount                         $ 0 2,100,000
IPO [Member] | Common Stock [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Stock issued during period, value, new issues                           $ 25,000
Stock issued during period, shares, new issues                           2,500,000
Over-Allotment Option [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Class of warrant or right, number of securities called by warrants or rights               3,272,500            
Class of warrant or right, exercise price of warrants or rights               $ 6.60            
Warrant expiration period               5 years            
Expiration date of warrants issued                         May 08, 2020  
Over-Allotment Option [Member] | Common Stock [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Class of warrant or right, number of securities called by warrants or rights               185,250            
Scenario, Plan [Member] | Cowen and Company, LLC [Member] | At the Market Offering [Member] | Sales Agreement [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Stock issued during period, value, new issues       $ 11,500,000                    
Proceeds from issuance of common stock, net of issuance costs     $ 4,400,000                   $ 4,400,000  
Gross proceeds from sale of common stock     4,700,000                   4,700,000  
Maximum commission percentage on gross proceeds       3.00%                    
Remaining availability under at the market offering     $ 6,800,000                   $ 6,800,000  
Scenario, Plan [Member] | Cowen and Company, LLC [Member] | At the Market Offering [Member] | Sales Agreement [Member] | Common Stock [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Stock issued during period, shares, new issues     3,600,000                   3,600,000  
Scenario, Plan [Member] | Maximum [Member] | Cowen and Company, LLC [Member] | At the Market Offering [Member] | Sales Agreement [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Aggregate gross proceeds from issuance of common stock       $ 25,000,000                    
Subsequent Event [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Share-based compensation arrangement by share-based payment award, options, grants in period, gross   723,300                        
Share based compensation arrangements by share based payment award options grants in period exercise price   $ 1.03                        
Subsequent Event [Member] | Scenario, Plan [Member] | Cowen and Company, LLC [Member] | At the Market Offering [Member] | Sales Agreement [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Proceeds from issuance of common stock, net of issuance costs $ 2,100,000                          
Gross proceeds from sale of common stock 2,200,000                          
Remaining availability under at the market offering $ 4,600,000                          
Subsequent Event [Member] | Scenario, Plan [Member] | Cowen and Company, LLC [Member] | At the Market Offering [Member] | Sales Agreement [Member] | Common Stock [Member]                            
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                            
Stock issued during period, shares, new issues 2,100,000