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Merck GHI Financing (Details Textual) - USD ($)
12 Months Ended
Jul. 14, 2015
Dec. 31, 2016
Dec. 31, 2015
Common Stock and Note Purchase Agreement [Line Items]      
Proceeds from issuance of common stock, net of issuance costs   $ 4,405,973 $ 17,366,620
Adjustments to additional paid in capital, stock issued, issuance costs     $ 58,566
Merck GHI Financing Agreement [Member]      
Common Stock and Note Purchase Agreement [Line Items]      
Stock issued during period, shares, new issues 1,136,364    
Shares issued, price per share $ 4.40    
Proceeds from issuance of common stock, net of issuance costs $ 5,000,000    
Debt instrument, interest rate, stated percentage 8.00%    
Debt instrument, face amount $ 1,000,000    
Fees related to common stock and debt transaction 50,000    
Deferred debt issuance costs 8,000    
Adjustments to additional paid in capital, stock issued, issuance costs $ 42,000