Stockholders' equity (Details 1)	9 Months Ended
Sep. 30, 2016 $ / shares shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shares of Common Stock Subject to Warrants	10,506,524
August 2007
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Exercise Price \| $ / shares	$ 7.91
Expiration	2017-08
Shares of Common Stock Subject to Warrants	8,921
March 2008
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Exercise Price \| $ / shares	$ 790.54
Expiration	2018-03
Shares of Common Stock Subject to Warrants	46
November 2009
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Exercise Price \| $ / shares	$ 7.91
Expiration	2019-11
Shares of Common Stock Subject to Warrants	6,674
January 2010
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Exercise Price \| $ / shares	$ 7.91
Expiration	2020-01
Shares of Common Stock Subject to Warrants	6,674
March 2010
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Exercise Price \| $ / shares	$ 7.91
Expiration	2020-03
Shares of Common Stock Subject to Warrants	1,277
November 2011
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Exercise Price \| $ / shares	$ 7.91
Expiration	2021-11
Shares of Common Stock Subject to Warrants	5,213
December 2011
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Exercise Price \| $ / shares	$ 7.91
Expiration	2021-12
Shares of Common Stock Subject to Warrants	664
March 2012
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Exercise Price \| $ / shares	$ 109.90
Expiration	2019-03
Shares of Common Stock Subject to Warrants	4,125
February 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Exercise Price \| $ / shares	$ 6.60
Expiration	2025-02
Shares of Common Stock Subject to Warrants	225,011
May 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Exercise Price \| $ / shares	$ 6.60
Expiration	2020-05
Shares of Common Stock Subject to Warrants	3,457,750
May 2016
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Exercise Price \| $ / shares	$ 1.31
Expiration	2021-05
Shares of Common Stock Subject to Warrants	4,739,348
June 2016
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Exercise Price \| $ / shares	$ 1.31
Expiration	2021-05
Shares of Common Stock Subject to Warrants	2,050,821

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- Definition

Exercise price per share or per unit of warrants or rights outstanding.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 235
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08.(i)(4))
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Number of equity instruments other than options outstanding, including both vested and non-vested instruments.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(1)(i)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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-Name Accounting Standards Codification
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