Going Concern and Management’s Plans (Details) $ / shares in Units, € in Thousands						1 Months Ended	9 Months Ended		12 Months Ended
	Apr. 30, 2022 EUR (€)	Feb. 28, 2022 USD ($)	Oct. 18, 2021 USD ($) $ / shares shares	Mar. 09, 2021 USD ($) $ / shares shares	Feb. 11, 2021 USD ($) $ / shares shares	May 23, 2022 EUR (€)	Sep. 30, 2022 USD ($) $ / shares shares	Sep. 30, 2021 USD ($)	Dec. 31, 2021 USD ($) $ / shares shares	Oct. 31, 2022 $ / shares shares	Feb. 11, 2020 USD ($)
Going Concern and Management’s Plans (Details) [Line Items]
Repaid amount							$ 8,697,587	$ 441,076
Preferred stock stated value per share | $ / shares							$ 0.01		$ 0.01
Holder pursuant to company issued to Holder securities [Member] | Warrant [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Aggregate gross proceeds				$ 9,650,000
European Investment Bank [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Borrowings under Guaranteed Investment Agreements | €						€ 8,000
European Investment Bank [Member] | Tranche One [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Borrowings under Guaranteed Investment Agreements | €						3,350
Repaid amount | €	€ 5,000
European Investment Bank [Member] | Tranche Two [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Borrowings under Guaranteed Investment Agreements | €						3,000
European Investment Bank [Member] | Tranche Three [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Borrowings under Guaranteed Investment Agreements | €						€ 5,000
2022 ATM Offering [Member] | H.C. Wainwright & Co., LLC [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Old maximum value of common stock shares issuable through sales agent							$ 10,650,000
Company sold shares | shares							1,714,882
Gross proceeds							$ 1,030,000.00
Net proceeds							990,000
Reduction in stock that can be sold in the 2022 ATM offering							$ 3,500,000
PPI [Member] | European Investment Bank [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Old PPI debt, percentage						0.30%
Increased PPI debt, percentage						0.75%
October 2021 Offering [Member] | Healthcare-focused Institutional Investor [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Gross proceeds			$ 15,000,000
Net proceeds			$ 13,900,000
Shares issued | shares			150,000
Preferred stock stated value per share | $ / shares			$ 100
Common stock conversion price | $ / shares			$ 2
Converted common shares | shares			150,000						7,500,000
Exercise price per warrant | $ / shares			$ 2.05
Warrants expiry period			5 years
Net proceeds			$ 13,900,000
October 2021 Offering [Member] | Healthcare-focused Institutional Investor [Member] | Warrant [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Aggregate warrants | shares			7,500,000
Warrants to purchase shares of common stock | shares			7,500,000
October 2021 Offering [Member] | Investor [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Exercise price per warrant | $ / shares			$ 2.05
2020 PIPE [Member] | Healthcare-focused U.S. Institutional Investor [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Warrants issued and exercised | shares				4,842,615
Exercise Agreement [Member] | Holder [Member] | Warrant [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Exercise price per warrant | $ / shares				$ 3.56
Warrants to purchase shares of common stock | shares				0.65
Aggregate number of warrants | shares				3,147,700
Warrants expiry period				5 years
Aggregate gross proceeds				$ 255,751
Purchase Agreement [Member] | Alliance Global Partners [Member] | Warrant [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Received cash fees given to placement agent				$ 200,000
February 2021 Offering [Member] | Healthcare-focused Institutional Investor [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Gross proceeds					$ 25,000,000
Shares issued | shares					2,784,184
Converted common shares | shares					2.99
Exercise price per warrant | $ / shares					$ 0.01
Net proceeds					$ 23,500,000
Each share of common stock and accompanying common warrant | $ / shares					$ 3
February 2021 Offering [Member] | Healthcare-focused Institutional Investor [Member] | Warrant [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Pre-funded warrants | shares					5,549,149				5,549,149
February 2021 Offering [Member] | Investor [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Exercise price per warrant | $ / shares					$ 3.55
Warrants to purchase shares of common stock | shares					4,166,666
Warrants expiry period					5 years 6 months
Each share of common stock and accompanying common warrant | $ / shares					$ 3
February 2021 Offering [Member] | Investor [Member] | Warrant [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Pre-funded warrant and accompanying common warrant offering price | $ / shares					2.99
Exercise price per pre-funded warrant | $ / shares					$ 0.01
October 2021 Offering [Member] | Healthcare-focused Institutional Investor [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Warrants to purchase shares of common stock | shares										7,500,000
Warrants to purchase of common stock price per share | $ / shares										$ 0.377
Exercise Agreement [Member] | PIPE Financing [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Warrants to purchase shares of common stock | shares										3,147,700
Warrants to purchase of common stock price per share | $ / shares										$ 0.377
February 2021 Offering [Member] | Healthcare-focused Institutional Investor [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Warrants to purchase shares of common stock | shares										4,166,666
Warrants to purchase of common stock price per share | $ / shares										$ 0.377
Nasdaq Stock Market LLC [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Consecutive business days		30
Regain compliance days		180
Regain compliance extension granted days		180
Minimum bid price to remain on NASDAQ		$ 1
2020 ATM Offering [Member] | Common Stock [Member] | H.C. Wainwright & Co., LLC [Member]
Going Concern and Management’s Plans (Details) [Line Items]
Gross proceeds									$ 1,550,000
Shares issued | shares									680,000
Net proceeds									$ 1,480,000
Aggregate of common stock											$ 22,100,000