Consolidated Statements of Stockholders' Equity - USD ($)	Common Stock [Member]	Preferred Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Accumulated Deficit [Member]	Total
Balance at Dec. 31, 2019	$ 55,823		$ 178,779,814	$ (17,315)	$ (174,524,983)	$ 4,293,339
Balance (in shares) at Dec. 31, 2019	5,582,280
Offering of common stock and warrants, net of issuance costs	$ 48,426		9,240,703			9,289,129
Offering of common stock and warrants, net of issuance costs (in shares)	4,842,615
Beneficial conversion option on convertible preferred stock
Deemed dividend on beneficial conversion feature
At the market offering, net of offering costs	$ 75,216		15,746,706			15,821,922
At the market offering, net of offering costs (in shares)	7,521,610
Warrant exercises	$ 43,410		8,638,590			8,682,000
Warrant exercises (in shares)	4,341,000
Issuance of RSUs	$ 59		(59)
Issuance of RSUs (in shares)	5,916
Stock compensation expense			316,086			316,086
Shares issued to settle convertible notes	$ 7,639		1,443,158			1,450,797
Shares issued to settle convertible notes (in shares)	763,905
Shares issued in business combination	$ 20,282		4,827,135			4,847,417
Shares issued in business combination (in shares)	2,028,208
Value of equity awards assumed in business combination			136,912			136,912
Foreign currency translation				2,564,497		2,564,497
Net loss					(26,210,844)	(26,210,844)
Balance at Dec. 31, 2020	$ 250,855		219,129,045	2,547,182	(200,735,827)	21,191,255
Balance (in shares) at Dec. 31, 2020	25,085,534
Offering of common stock and warrants, net of issuance costs	$ 83,334		23,390,628			23,473,962
Offering of common stock and warrants, net of issuance costs (in shares)	8,333,333
Offering of preferred stock and warrants, net of issuance costs		$ 1,500	13,849,759			13,851,259
Offering of preferred stock and warrants, net of issuance costs, shares		150,000
Conversion of preferred stock into common stock	$ 75,000	$ (1,500)	(73,500)
Conversion of preferred stock into common stock, shares	7,500,000	(150,000)
Beneficial conversion option on convertible preferred stock			7,166,752			7,166,752
Deemed dividend on beneficial conversion feature			(7,166,752)			(7,166,752)
At the market offering, net of offering costs	$ 6,800		1,477,033			1,483,833
At the market offering, net of offering costs (in shares)	680,000
Warrant exercises	$ 48,476		9,045,696			9,094,172
Warrant exercises (in shares)	4,847,615
Proceeds from the issuance of warrants			255,751			255,751
Warrant inducement			7,755,541			7,755,541
Issuance of RSUs	$ 38		(38)
Issuance of RSUs (in shares)	3,768
Stock compensation expense			878,575			878,575
Shares issued in business combination
Foreign currency translation				(1,961,556)		(1,961,556)
Net loss					(34,805,712)	(34,805,712)
Balance at Dec. 31, 2021	$ 464,503		$ 275,708,490	$ 585,626	$ (235,541,539)	$ 41,217,080
Balance (in shares) at Dec. 31, 2021	46,450,250