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Going Concern and Management's Plans (Details) - USD ($)
1 Months Ended 12 Months Ended
Dec. 08, 2021
Mar. 09, 2021
Feb. 11, 2021
Oct. 18, 2021
Nov. 25, 2020
Dec. 31, 2021
Dec. 31, 2020
Feb. 11, 2020
Conversion of Stock [Line Items]                
Preferred Stock, Par or Stated Value Per Share           $ 0.01 $ 0.01  
Proceeds from issuance of common stock, net of issuance costs           $ 1,483,833 $ 15,821,922  
Healthcare-focused Institutional Investor [Member] | October 2021 Offering [Member]                
Conversion of Stock [Line Items]                
Convertible preferred stock 7,500,000     7,500,000   7,500,000    
Stock issued during period, shares, new issues 150,000     150,000        
Preferred Stock, Par or Stated Value Per Share       $ 100        
Conversion preferred stock per share       $ 2.00        
Gross proceeds from sale of common stock       $ 15,000,000.0        
Proceeds from issuance of common stock, net of issuance costs       $ 13,900,000        
Class of warrant or right, exercise price of warrants or rights       $ 2.05        
Warrants exercisable period       6 months        
Warrants expiry period       5 years        
Healthcare-focused Institutional Investor [Member] | October 2021 Offering [Member] | Warrants [Member]                
Conversion of Stock [Line Items]                
Stock issued during period, shares, new issues       7,500,000        
Healthcare-focused Institutional Investor [Member] | February 2021 Offering [Member]                
Conversion of Stock [Line Items]                
Stock issued during period, shares, new issues     2,784,184          
Gross proceeds from sale of common stock     $ 25,000,000.0          
Proceeds from issuance of common stock, net of issuance costs     $ 23,500,000          
Sale of stock, description of transaction     each pre-funded warrant exercisable for one share of common stock          
Healthcare-focused Institutional Investor [Member] | February 2021 Offering [Member] | Pre Funded Warrant [Member]                
Conversion of Stock [Line Items]                
Stock issued during period, shares, new issues     5,549,149     5,549,149    
Sale of stock, description of transaction           each pre-funded warrant exercisable for one share of common stock.    
Warrants exercised     4,166,666          
Holder [Member] | Exercise Agreement [Member] | Warrant [Member]                
Conversion of Stock [Line Items]                
Class of warrant or right, exercise price of warrants or rights   $ 3.56            
Warrants expiry period   5 years            
Number of each warrant issue to purchase common stock   0.65            
New warrants issue against outstanding warrants   3,147,700            
Payment to purchase new warrants   $ 255,751            
Alliance Global Partners [Member] | Purchase Agreement [Member] | Warrant [Member]                
Conversion of Stock [Line Items]                
Cash fee compensation   $ 200,000            
Investor [Member] | February 2021 Offering [Member]                
Conversion of Stock [Line Items]                
Offering of common stock and warrants     4,166,666          
Shares issued, price per share     $ 3.00          
Class of warrant or right, exercise price of warrants or rights     $ 3.55          
Warrants exercisable period     6 months          
Warrants expiry period     5 years 6 months          
Investor [Member] | February 2021 Offering [Member] | Pre Funded Warrant [Member]                
Conversion of Stock [Line Items]                
Shares issued, price per share     $ 2.99          
Class of warrant or right, exercise price of warrants or rights     $ 0.01          
Healthcare-focused U.S. Institutional Investor [Member] | 2020 PIPE [Member]                
Conversion of Stock [Line Items]                
Stock issued during period, shares, new issues         2,245,400      
Shares issued, price per share         $ 2.065      
Gross proceeds from sale of common stock         $ 10,000,000.0      
Proceeds from issuance of common stock, net of issuance costs         $ 9,300,000      
Sale of stock, description of transaction         with each pre-funded warrant exercisable for one share of common stock      
Class of warrant or right, exercise price of warrants or rights         $ 1.94      
Warrants exercisable period         6 months      
Warrants exercised   4,842,615     4,842,615      
Warrants expiry period         5 years 6 months      
New warrants issue against outstanding warrants         2,245,400      
Healthcare-focused U.S. Institutional Investor [Member] | 2020 PIPE [Member] | Maximum [Member]                
Conversion of Stock [Line Items]                
Stock issued during period, shares, new issues         2,245,400      
Healthcare-focused U.S. Institutional Investor [Member] | 2020 PIPE [Member] | Pre Funded Warrant [Member]                
Conversion of Stock [Line Items]                
Stock issued during period, shares, new issues         2,597,215      
Shares issued, price per share         $ 2.055      
Sale of stock, description of transaction           each pre-funded warrant exercisable for one share of common stock    
Warrants exercised         2,597,215      
New warrants issue against outstanding warrants         2,597,215   2,597,215  
H.C. Wainwright & Co., LLC [Member] | Common Stock [Member] | 2020 ATM Offering [Member]                
Conversion of Stock [Line Items]                
Stock issued during period, shares, new issues           680,000 7,521,610  
Gross proceeds from sale of common stock           $ 1,550,000 $ 16,700,000  
Proceeds from issuance of common stock, net of issuance costs           $ 1,480,000 $ 15,800,000  
H.C. Wainwright & Co., LLC [Member] | Common Stock [Member] | 2020 ATM Offering [Member] | Maximum [Member]                
Conversion of Stock [Line Items]                
Common shares available for future issuance amount               $ 22,100,000
Holder pursuant to company issued to Holder securities [Member] | Warrants [Member]                
Conversion of Stock [Line Items]                
Proceeds from issuance of warrant   $ 9,650,000