Condensed Consolidated Statements of Stockholders' Equity (unaudited) - USD ($)	Common Stock [Member]	Preferred Stock [Member]	Additional Paid In Capital [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Accumulated Deficit [Member]	Total
Balance at Dec. 31, 2019	$ 55,823		$ 178,779,814	$ (17,315)	$ (174,524,983)	$ 4,293,339
Balance (in shares) at Dec. 31, 2019	5,582,280
Inducement expense related to warrant reprice
Proceeds from issuance of common stock warrants
At the market offering, net of offering costs	$ 28,149		5,449,283			5,477,432
At the market offering, net of offering costs, shares	2,814,934
Common stock warrant exercises	$ 40,710		8,101,290			8,142,000
Common stock warrant exercises, shares	4,071,000
Stock compensation expense			79,740			79,740
Foreign currency translation				39,477		39,477
Net loss					(3,949,294)	(3,949,294)
Balance at Mar. 31, 2020	$ 124,682		192,410,127	22,162	(178,474,277)	14,082,694
Balance (in shares) at Mar. 31, 2020	12,468,214
Balance at Dec. 31, 2019	$ 55,823		178,779,814	(17,315)	(174,524,983)	4,293,339
Balance (in shares) at Dec. 31, 2019	5,582,280
Balance at Dec. 31, 2020	$ 250,855		219,129,045	2,547,182	(200,735,827)	21,191,255
Balance (in shares) at Dec. 31, 2020	25,085,534
Offering of common stock and warrants, net of issuance costs	$ 83,334		23,390,628			23,473,962
Offering of common stock and warrants, net of issuance costs (in shares)	8,333,333
Inducement expense related to warrant reprice			7,755,541			7,755,541
Common stock warrant exercises, net of issuance costs	$ 48,476		9,045,696			9,094,172
Common stock warrant exercises, net of issuance costs, shares	4,847,615
Proceeds from issuance of common stock warrants			255,751			255,751
Stock compensation expense			189,670			189,670
Foreign currency translation				(1,078,479)		(1,078,479)
Net loss					(14,850,591)	(14,850,591)
Balance at Mar. 31, 2021	$ 382,665		$ 259,766,331	$ 1,468,703	$ (215,586,418)	$ 46,031,281
Balance (in shares) at Mar. 31, 2021	38,266,482