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Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($)
Dec. 31, 2018
Dec. 31, 2017
Income Tax Disclosure [Abstract]    
NOL carryforward $ 49,480,731 $ 46,326,407
R&E credit carryforward 2,559,479 2,559,479
Share-based compensation 329,796 345,088
Inventory reserve 19,068 45,338
Depreciation 0 71,756
Interest expense 51,152 0
Accruals and other 284,662 247,093
Total deferred tax assets 52,724,888 49,595,161
Valuation allowance (52,348,036) (49,251,408)
Deferred tax liabilities:    
Intangible assets (256,011) (343,753)
Depreciation (120,841) 0
Net $ 0 $ 0