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Consolidated Statements of Cash Flows - USD ($)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Cash flows from operating activities    
Net loss $ (15,419,308) $ (19,166,753)
Adjustments to reconcile net loss to net cash used in operating activities    
Depreciation and amortization 669,088 656,047
Loss on disposal of property and equipment 0 6,309
Noncash interest expense 185,294 4,527
Share-based compensation 911,398 945,461
Inventory obsolescence 0 113,465
Change in fair value of warrant liabilities (144,064) 0
Unamortized discount on bridge loan at repayment 85,932 0
Changes in operating assets and liabilities:    
Accounts receivable (260,471) 136,226
Inventory 161,027 20,179
Other assets (315,688) 263,882
Accounts payable (563,357) (53,229)
Accrued compensation and other liabilities 399,224 (163,223)
Deferred revenue (12,955) (13,528)
Net cash used in operating activities (14,303,880) (17,250,637)
Cash flows from investing activities    
Purchases of property and equipment (net of proceeds on disposals) (276,950) (123,514)
Net cash used in investing activities (276,950) (123,514)
Cash flows from financing activities    
Proceeds from issuance of common stock, net of issuance costs 3,808,836 4,405,973
Proceeds from issuance of promissory notes, net of issuance costs 0 204,895
Proceeds from private offering of common stock, preferred stock and warrants, net of issuance costs 0 9,460,749
Proceeds from issuance of units, net of selling costs 8,754,882 0
Proceeds from exercise of stock options and warrants 76,537 23,771
Proceeds from debt, net of issuance costs 1,168,222 0
Payments on debt (1,255,198) (178,997)
Payments on capital lease obligations (205,085) (251,701)
Net cash provided by financing activities 12,348,194 13,664,690
Effects of exchange rates on cash (37,517) 12,565
Net decrease in cash and cash equivalents (2,270,153) (3,696,896)
Cash and cash equivalents at beginning of year 4,117,324 7,814,220
Cash and cash equivalents at end of year 1,847,171 4,117,324
Supplemental disclosure of cash flow information    
Cash paid for interest 48,211 58,564
Supplemental disclosures of noncash investing and financing activities:    
Unpaid deferred offering costs 48,398 0
Shares issued to settle obligations 133,245 0
Issuance of placement agent warrant $ 93,677 $ 0