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Consolidated Statements of Cash Flows - USD ($)
9 Months Ended 12 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Dec. 31, 2016
Dec. 31, 2015
Cash flows from operating activities        
Net loss $ (12,454,647) $ (14,406,745) $ (19,166,753) $ (17,352,073)
Adjustments to reconcile net loss to net cash used in operating activities        
Depreciation and amortization 499,651 494,828 656,047 624,653
Loss on disposal of property and equipment 0 6,308 6,309 0
Deferred tax benefit 0 0 0 (129,095)
Noncash interest expense 65,511 3,126 4,527 1,598,312
Share-based compensation 722,304 706,648 945,461 1,445,088
Inventory obsolescence 0 109,367 113,465 0
Change in fair value of derivative financial instruments (124,139) 0 0 647,342
Unamortized discount on bridge loan at repayment 85,932 0 0 0
Other non-cash items 0 0 0 24,010
Changes in operating assets and liabilities, net of effects of acquisition:        
Accounts receivable 72,466 231,960 136,226 359,298
Inventory 231,239 (113,560) 20,179 424,505
Other assets (337,999) 124,133 263,882 (319,305)
Accounts payable (293,388) (349,780) (53,229) 196,444
Accrued compensation and other liabilities 337,562 313,644 (163,223) (1,508,937)
Deferred revenue (6,158) 13,499 (13,528) (288,246)
Net cash used in operating activities (11,201,666) (12,866,572) (17,250,637) (14,278,004)
Cash flows from investing activities        
Cash acquired in business combinations     0 1,367,211
Purchases of property and equipment (net of proceeds on disposals) (142,687) (87,533) (123,514) (185,296)
Net cash (used in)/provided by investing activities (142,687) (87,533) (123,514) 1,181,915
Cash flows from financing activities        
Proceeds from issuance of common stock, net of issuance costs 3,426,050 124 4,405,973 17,366,620
Proceeds from issuance of convertible notes and warrants, net of issuance costs     0 1,388,815
Proceeds from issuance of promissory notes, net of issuance costs 0 204,895 204,895 1,741,667
Proceeds from issuance of units, net of selling costs 8,754,882 0    
Proceeds from exercise of stock options and warrants 48,179 23,771 23,771 2,293
Proceeds from private offering of common stock, preferred stock and warrants, net of issuance costs 0 9,460,751 9,460,749 0
Proceeds from debt, net of issuance costs 1,168,222 0    
Payments on debt (1,146,287) (101,796) (178,997) (155,000)
Payments on capital lease obligations (156,161) (188,231) (251,701) (175,317)
Net cash provided by financing activities 12,094,885 9,399,514 13,664,690 20,169,078
Effects of exchange rates on cash (13,825) 1,276 12,565 (8,286)
Net (decrease)/increase in cash and cash equivalents 736,707 (3,553,315) (3,696,896) 7,064,703
Cash and cash equivalents at beginning of period 4,117,324 7,814,220 7,814,220 749,517
Cash and cash equivalents at end of period 4,854,031 4,260,905 4,117,324 7,814,220
Supplemental disclosure of cash flow information        
Cash paid for interest 108,463 46,022 58,564 194,288
Supplemental disclosures of noncash investing and financing activities:        
Acquisition of equipment purchased through capital leases     0 580,477
Common stock issued in business combination     0 2,584,090
Conversion of convertible promissory notes to Series A preferred stock     0 3,000,000
Conversion of series A preferred stock into common shares     0 8,183,661
Exchange of demand notes for IPO units     0 2,100,000
Exchange of demand note for convertible debt     $ 0 $ 300,000
Unpaid deferred offering costs 0 137,178    
Shares issued to settle obligations 110,000 0    
Issuance of placement agent warrant $ 93,677 $ 0