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Consolidated Statements of Operations and Comprehensive Loss - USD ($)
3 Months Ended 12 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Dec. 31, 2016
Dec. 31, 2015
Revenue        
Product sales $ 734,502 $ 947,219 $ 3,524,178 $ 2,701,142
Laboratory services 16,105 129,420 228,904 120,476
Collaboration revenue 21,164 0 272,603 336,102
Total revenue 771,771 1,076,639 4,025,685 3,157,720
Operating expenses        
Cost of products sold 424,950 345,967 1,658,571 1,179,771
Cost of services 100,233 315,709 631,333 367,802
Research and development 2,122,515 1,953,429 8,613,236 6,002,941
General and administrative 1,969,216 1,538,046 6,602,608 5,834,642
Sales and marketing 1,105,586 1,399,435 5,529,274 4,305,444
Transaction expenses     0 526,283
Total operating expenses 5,722,500 5,552,586 23,035,022 18,216,883
Operating loss (4,950,729) (4,475,947) (19,009,337) (15,059,163)
Other expense        
Interest and other (expense)/income 21 173 (5,967) 26,657
Interest expense (29,844) (41,734) (143,347) (1,801,320)
Foreign currency transaction losses 2,620 11,328 (8,102) 0
Change in fair value of derivative financial instruments     0 (647,342)
Total other expense (27,203) (30,233) (157,416) (2,422,005)
Loss before income taxes (4,977,932) (4,506,180) (19,166,753) (17,481,168)
Provision for income taxes 0 0 0 (129,095)
Net loss (4,977,932) (4,506,180) (19,166,753) (17,352,073)
Preferred stock dividends and beneficial conversion 0 0 (332,550) (243,762)
Net loss available to common stockholders $ (4,977,932) $ (4,506,180) $ (19,499,303) $ (17,595,835)
Net loss per common share - basic and diluted $ (0.19) $ (0.36) $ (1.10) $ (2.20)
Weighted average shares outstanding - basic and diluted 26,079,461 12,568,941 17,667,557 7,980,995
Net loss $ (4,977,932) $ (4,506,180) $ (19,166,753) $ (17,352,073)
Other comprehensive income/(loss) - foreign currency translation (3,757) (1,112) 7,235 (1,059)
Comprehensive loss $ (4,981,689) $ (4,507,292) $ (19,159,518) $ (17,353,132)