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Savant Arrangements (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 9 Months Ended 12 Months Ended
Feb. 29, 2016
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Dec. 31, 2015
Legal expenses       $ 802    
Fair value of warrants   $ 518   518    
Warrant expense included in research and development expenses   28,000        
Research and development   $ 1,741 $ 3,845 7,805 $ 13,082  
Savant Neglected Diseases, LLC [Member]            
Monthly payment amount $ 88     263    
Payments for in process research and development 500     2,688   $ 250
Initial payment amount $ 3,000     2,500    
Legal expenses       $ 100    
Number of shares called by warrant 200,000 200,000   200,000    
Exercise price of warrant $ 2.25 $ 2.25   $ 2.25    
Milestone payments and certain other contingent payments   $ 21,000   $ 21,000    
Exercise period of warrant 5 years     5 years    
Fair value of warrants   670   $ 670    
Warrant expense included in research and development expenses   $ 87,500 $ 244,000      
Research and development       $ 3,250    
Savant Neglected Diseases, LLC [Member] | Exercisable upon reaching certain milestones [Member]            
Percentage of warrants exercisable 75.00%     75.00%    
Savant Neglected Diseases, LLC [Member] | Exercisable Immediately [Member]            
Percentage of warrants exercisable 25.00%     25.00%