Restructuring Charges (Tables)

9 Months Ended

Sep. 30, 2016

Restructuring and Related Activities [Abstract]

Schedule of activity in accrued restructuring balance, included within accrued compensation

(in thousands)	Contractterminationcosts - R&D			Salaries andbenefits - R&D			Salaries andbenefits - G&A			Total
Balance as of December 31, 2014	$	1,185		$	—		$	—		$	1,185
Accrued		—			522			82			604
Paid		(479	)		(257	)		—			(736	)
Balance as of March 31, 2015		706			265			82			1,053
Accrued		—			57			122			179
Paid		(135	)		(142	)		—			(277	)
Balance as of June 30, 2015		571			180			204			955
Accrued		—			—			—			—
Adjustments		(78	)		—			—			(78	)
Paid		(493	)		(148	)		(136	)		(777	)
Balance as of September 30, 2015		—			32			68			100
Accrued		—			588			807			1,395
Paid		—			(620	)		(864	)		(1,484	)
Balance as of December 31,2015		—			—			11			11
Accrued		—			—			—			—
Paid		—			—			—			—
Balance as of March 31, June 30 and September   30, 2016	$	—		$	—		$	11		$	11