Share Based Compensation (Tables)

9 Months Ended

Sep. 30, 2016

Stockholders' Equity Note [Abstract]

Summary of stock option activity

				Weighted
				Average
				Exercise
	Options			Price
Outstanding at December 31, 2015		465,401		$	19.29
Granted		—			—
Exercised		—			—
Cancelled (forfeited)		(3,416	)		5.86
Cancelled (expired)		(63,997	)		33.51
Outstanding at March 31, 2016		397,988		$	17.12
Granted		—			—
Exercised		—			—
Cancelled (forfeited)		—			—
Cancelled (expired)		(9,551	)		12.39
Outstanding at June 30, 2016		388,437		$	17.23
Granted		1,678,022			3.38
Exercised		—			—
Cancelled (forfeited)		—			—
Cancelled (expired)		(30,342	)		16.83
Outstanding at September 30, 2016		2,036,117		$	5.82

Schedule of fair value-based measurement of stock options granted under the entity's stock plans estimated using Black-Scholes model

	Three Months Ended September 30, 2016
Exercise price	$	3.38
Market value	$	3.38
Risk-free rate		1.41%
Expected term	6.0 years
Expected volatility		84.8%
Dividend yield		-

Schedule of total stock-based compensation expense recognized

	Three Months				Nine Months
	Ended September 30,				Ended September 30,
(in thousands)	2016		2015		2016		2015
General and administrative	$	273	$	137	$	275	$	466
Research and development		40		134		42		447
	$	313	$	271	$	317	$	913