Share Based Compensation (Tables)

3 Months Ended

Mar. 31, 2016

Stockholders' Equity Note [Abstract]

Summary of stock option activity

				Weighted
				Average
				Exercise
	Options			Price
Outstanding at December 31, 2015		465,401			$	19.29
Granted		—				—
Exercised		—				—
Cancelled (forfeited)		(3,416	)			5.86
Cancelled (expired)		(63,997	)			33.51
Outstanding at March 31, 2016		397,988			$	17.12

Schedule of total stock-based compensation expense recognized

	Three Months
	Ended March 31,
(in thousands)	2016		2015
General and administrative	$	1	$	142
Research and development		1		163
	$	2	$	305