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Restructuring Charges (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Sep. 30, 2015
Sep. 30, 2014
Restructuring Cost and Reserve [Line Items]          
Balance at the beginning of the period $ 955 $ 1,053 $ 1,185 $ 1,185  
Additions based on charges during the period 179 604    
Deductions based on adjustments during the period (78)        
Deductions based on payments during the period (777) (277) (736)    
Balance at the end of the period $ 100 955 1,053 100  
Modification of stock options related to restructuring activities       $ 479
Reduction in workforce (as a percentage) 20.00%     20.00%  
Research And Development Expense [Member] | Contract Termination [Member]          
Restructuring Cost and Reserve [Line Items]          
Balance at the beginning of the period $ 571 706 1,185 $ 1,185  
Additions based on charges during the period      
Deductions based on adjustments during the period (78)        
Deductions based on payments during the period (493) (135) (479)    
Balance at the end of the period 571 706  
Research And Development Expense [Member] | Contract Termination [Member] | Restatement Adjustment [Member]          
Restructuring Cost and Reserve [Line Items]          
Reduction in accrued research and clinical liabilities   312      
Research And Development Expense [Member] | Employee Severance [Member]          
Restructuring Cost and Reserve [Line Items]          
Balance at the beginning of the period 180 265  
Additions based on charges during the period 57 522    
Deductions based on adjustments during the period        
Deductions based on payments during the period (148) (142) (257)    
Balance at the end of the period 32 180 265 32  
Research And Development Expense [Member] | Employee Severance [Member] | Employee Stock Option [Member] | Restructuring Plan [Member]          
Restructuring Cost and Reserve [Line Items]          
Value of stock options fair value modification       384  
General And Administrative Expense [Member] | Employee Severance [Member]          
Restructuring Cost and Reserve [Line Items]          
Balance at the beginning of the period 204 82  
Additions based on charges during the period 122 82    
Deductions based on adjustments during the period        
Deductions based on payments during the period (136)    
Balance at the end of the period $ 68 $ 204 $ 82 68  
General And Administrative Expense [Member] | Employee Severance [Member] | Employee Stock Option [Member] | Restructuring Plan [Member]          
Restructuring Cost and Reserve [Line Items]          
Value of stock options fair value modification       $ 95