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Restructuring Charges (Tables)
 9 Months Ended
Sep. 30, 2015
Restructuring and Related Activities [Abstract]  
Schedule of activity in accrued restructuring balance, included within accrued compensation
(in thousands)
  
Contract
termination
 costs - R&D
    
Salaries and
 benefits -
R&D
    
Salaries and
 benefits -
G&A
    
Total
  
Balance as of December 31, 2014
  
$
1,185
    
$
—
    
$
—
    
$
1,185
  
Accrued
    
—
      
522
      
82
      
604
  
Paid
    
(479
)
    
(257
)
    
—
      
(736
)
Balance as of March 31, 2015
  
$
706
    
$
265
    
$
82
    
$
1,053
  
Accrued
    
—
      
57
      
122
      
179
  
Paid
    
(135
)
    
(142
)
    
—
      
(277
)
Balance as of June 30, 2015
  
$
571
    
$
180
    
$
204
    
$
955
  
Accrued
    
—
      
—
      
—
      
—
  
Adjustments
    
(78
)
    
—
      
—
      
(78
)
Paid
    
(493
)
    
(148
)
    
(136
)
    
(777
)
Balance as of September 30, 2015
  
$
-
    
$
32
    
$
68
    
$
100