X0306 4 2022-05-18 0 0001192448 GLAUKOS Corp GKOS 0001293171 Kliman Gilbert H 467 FIRST STREET SUITE 201 LOS ALTOS CA 94022 1 0 0 0 Common Stock 2022-05-18 4 J 0 980 0.00 D 3896 D Common Stock 2022-05-18 4 J 0 980 0.00 A 13965 I By InterWest Venture Management Co. Common Stock 333917 I By InterWest Partners X, LP Common Stock 3362 I By InterWest Partners IX, LP The Reporting Person transferred these shares to InterWest Venture Management Company ("IVMC") for no consideration, pursuant to an agreement between the Reporting Person and InterWest Partners X, LP ("IP10") relating to compensation received in connection with his service as director of the Issuer. The shares are owned by IVMC. The Reporting Person is an officer, director and the sole shareholder of IVMC and has sole voting and investment control over the shares held by IVMC. Consists of shares owned by IP10. The general partner of IP10 is IMP10. The Reporting Person has shared voting and investment control over shares owned by IP10, and disclaims beneficial ownership of those securities, except to the extent of his pecuniary interest therein Consists of shares owned by InterWest Partners IX, LP ("IP9"). The Reporting Person is a Managing Director of InterWest Management Partners IX, LLC, the general partner of IP9. The Reporting Person has shared voting and investment control over shares owned by IP9, and disclaims beneficial ownership of those securities, except to the extent of his pecuniary interest therein. Includes 2,382 restricted stock units that have not yet vested or been delivered to the Reporting Person. /s/ Gilbert H. Kliman by Karen A. Wilson, Power of Attorney 2022-05-18