-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 MuyGJhzPH4bCVSRmAvrdEEQ4ObHqJgTmSLWPIVa7x04zn4AB2U6TarBG9C/KmKFW
 i+CzirWZ81Ng/6wdJSEO/A==

<SEC-DOCUMENT>0001144204-10-056724.txt : 20101101
<SEC-HEADER>0001144204-10-056724.hdr.sgml : 20101101
<ACCEPTANCE-DATETIME>20101101174840
ACCESSION NUMBER:		0001144204-10-056724
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20101026
FILED AS OF DATE:		20101101
DATE AS OF CHANGE:		20101101

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			REYNOLDS FRANCIS
		CENTRAL INDEX KEY:			0001503383

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-52089
		FILM NUMBER:		101155860

	MAIL ADDRESS:	
		STREET 1:		ONE BROADWAY
		STREET 2:		14TH FLOOR
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			INVIVO THERAPEUTICS HOLDINGS CORP.
		CENTRAL INDEX KEY:			0001292519
		STANDARD INDUSTRIAL CLASSIFICATION:	WHOLESALE-FURNITURE & HOME FURNISHINGS [5020]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			0331

	BUSINESS ADDRESS:	
		STREET 1:		ONE BROADWAY
		STREET 2:		14TH FLOOR
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142
		BUSINESS PHONE:		(617) 475-1520

	MAIL ADDRESS:	
		STREET 1:		ONE BROADWAY
		STREET 2:		14TH FLOOR
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02142

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Design Source, Inc.
		DATE OF NAME CHANGE:	20040602
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>v200603_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2010-10-26</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001292519</issuerCik>
        <issuerName>INVIVO THERAPEUTICS HOLDINGS CORP.</issuerName>
        <issuerTradingSymbol>DSGS.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001503383</rptOwnerCik>
            <rptOwnerName>REYNOLDS FRANCIS</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE BROADWAY</rptOwnerStreet1>
            <rptOwnerStreet2>14TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>CAMBRIDGE</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02142</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chief Executive Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, $0.00001 par value</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>15147660</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Non-qualified stock option</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.91</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2009-12-12</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2019-12-12</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common stock, par value $0.00001</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>784924</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Date shown is the date of grant.  Options vest as follows: 25% of the grant vests on each of the first, second, third and
 fourth anniversaries of the date of grant.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Francis M. Reynolds</signatureName>
        <signatureDate>2010-11-01</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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