<SEC-DOCUMENT>0001104659-18-041380-index.html : 20180620
<SEC-HEADER>0001104659-18-041380.hdr.sgml : 20180620
<ACCEPTANCE-DATETIME>20180620215537
ACCESSION NUMBER:		0001104659-18-041380
CONFORMED SUBMISSION TYPE:	S-1MEF
PUBLIC DOCUMENT COUNT:		4
<REFERENCE-462B>333-224424
FILED AS OF DATE:		20180620
DATE AS OF CHANGE:		20180620
EFFECTIVENESS DATE:		20180620

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			INVIVO THERAPEUTICS HOLDINGS CORP.
		CENTRAL INDEX KEY:			0001292519
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-1MEF
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-225768
		FILM NUMBER:		18910795

	BUSINESS ADDRESS:	
		STREET 1:		ONE KENDALL SQUARE
		STREET 2:		BUILDING 1400 EAST 4TH FLOOR
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		617-863-5524

	MAIL ADDRESS:	
		STREET 1:		ONE KENDALL SQUARE
		STREET 2:		BUILDING 1400 EAST 4TH FLOOR
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Design Source, Inc.
		DATE OF NAME CHANGE:	20040602
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-1MEF
<SEQUENCE>1
<FILENAME>a18-12086_5s1mef.htm
<DESCRIPTION>S-1MEF
<TEXT>
Document 1 - file: a18-12086_5s1mef.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>a18-12086_5ex5d1.htm
<DESCRIPTION>EX-5.1
<TEXT>
Document 2 - file: a18-12086_5ex5d1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>a18-12086_5ex23d1.htm
<DESCRIPTION>EX-23.1
<TEXT>
Document 3 - file: a18-12086_5ex23d1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>g120865kki001.gif
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: g120865kki001.gif

</DOCUMENT>
</SEC-DOCUMENT>